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PMID: 12106783 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Toll receptors, CD14, and macrophage activation and deactivation by LPS.

Microbes and infection ·Vol. 4 ·No. 9 ·2002-07-00 ·Pages 903-14

Dobrovolskaia MA, Vogel SN

Abstract

This review will focus on the molecular mechanisms of macrophage activation and desensitization by bacterial lipopolysaccharide (LPS). The most recent advances in the understanding of the function of the LPS receptor complex and its role in the development of the septic shock syndrome and endotoxin tolerance will be discussed.

MeSH Terms

Animals Bacteria/immunology Drosophila Proteins Humans Immunity, Innate/immunology Lipopolysaccharide Receptors/immunology Lipopolysaccharides/immunology Macrophage Activation Macrophages/immunology Membrane Glycoproteins/immunology Receptors, Cell Surface/immunology Shock, Septic/immunology,physiopathology Signal Transduction Toll-Like Receptors

Chemicals

Drosophila Proteins Lipopolysaccharide Receptors Lipopolysaccharides Membrane Glycoproteins Receptors, Cell Surface Toll-Like Receptors

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Dobrovolskaia Marina A

Department of Microbiology and Immunology, Uniformed Services University of Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.

Vogel Stefanie N

Article Info

Journal

Microbes and infection

Abbr.

Microbes Infect

ISSN

1286-4579

DOI

10.1016/s1286-4579(02)01613-1

Published

2002-07-00

Pages

903-14

Language

English

Region

France

NLM ID

100883508

Subset

Grants

NIAID NIH HHS · AI-18797 · United States

NIAID NIH HHS · AI-44936 · United States

External Links

PubMed source DOI: 10.1016/s1286-4579(02)01613-1 View journal details

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Toll receptors, CD14, and macrophage activation and deactivation by LPS.

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