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PMID: 12117997 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Mice that are congenic for the char2 locus are susceptible to malaria.

Infection and immunity ·Vol. 70 ·No. 8 ·2002-08-00 ·Pages 4750-3

Burt RA, Marshall VM, Wagglen J, Rodda FR, Senyschen D, Baldwin TM, Buckingham LA, Foote SJ

Abstract

A major advance has been made towards the positional cloning of char2 (a quantitative trait locus encoding resistance to Plasmodium chabaudi malaria). Mice congenic for the locus have been used to fine map the gene and to prove that char2 plays a significant role in the outcome of malarial infection, independently of other resistance loci.

MeSH Terms
Animals Female Genetic Predisposition to Disease/genetics Malaria/genetics Male Mice Mice, Inbred C3H Mice, Inbred C57BL Quantitative Trait, Heritable
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Burt Rachel A
The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria 3050, Australia.
Marshall Vikki M
Wagglen Jamie
Rodda Fleur R
Senyschen Danielle
Baldwin Tracey M
Buckingham Lynn A
Foote Simon J
References (8)
8 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.70.8.4750-4753.2002
Published
2002-08-00
Pages
4750-3
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC128146
Subset
IM
External Links
PubMed source DOI: 10.1128/IAI.70.8.4750-4753.2002 PMC Full Text View journal details
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