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PMID: 12121955 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae.

Antimicrobial agents and chemotherapy ·Vol. 46 ·No. 8 ·2002-08-00 ·Pages 2676-8

Baranwal S, Dey K, Ramamurthy T, Nair GB, Kundu M

Abstract

Quinolones are among the drugs of choice in the management of cholera caused by Vibrio cholerae. In this study, we demonstrate that, in addition to mutations detected in the target genes gyrA and parC, proton motive force-dependent efflux is involved in quinolone resistance in clinical isolates of V. cholerae.

MeSH Terms
Anti-Infective Agents/metabolism,pharmacology Cholera/microbiology DNA Gyrase/genetics,metabolism DNA Primers DNA Topoisomerase IV/genetics,metabolism Drug Resistance, Microbial Fluoroquinolones Genes, Bacterial/genetics Genome, Bacterial Humans Microbial Sensitivity Tests Mutation/genetics Reverse Transcriptase Polymerase Chain Reaction Vibrio cholerae/drug effects,genetics,metabolism
Chemicals
Anti-Infective Agents DNA Primers Fluoroquinolones DNA Topoisomerase IV DNA Gyrase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Baranwal Somesh
Department of Chemistry, Bose Institute, 93/1 Acharya Prafulla Chandra Road, Kolkata 700009, India.
Dey Keya
Ramamurthy T
Nair G Balakrish
Kundu Manikuntala
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16 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.46.8.2676-2678.2002
Published
2002-08-00
Pages
2676-8
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC127385
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.46.8.2676-2678.2002 PMC Full Text View journal details
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