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PMID: 1212421 Published · ppublish English Journal Article

Effects on serum complement of normal and pre-eclamptic pregnancy and of oral contraceptives.

British journal of experimental pathology ·Vol. 56 ·No. 5 ·1975-10-00 ·Pages 389-95

Tedder RS, Nelson M, Eisen V

Abstract

The complement system was studied in normal gestation and puerperium, in pre-eclampsia and in women taking oral contraceptives. In 12 normal pregnancies, CH50 titres, C4, C3, C6 and C7 were increased throughout pregnancy; the serum concentration of C1 inhibitor was decreased in the last 2 quarters but greatly raised after delivery. Oral oestrogen-progestogen contraceptives also raised C3 but in contrast to pregnancy lowered CH50, C6 and C7. The different effects of pregnancy and of oral contraceptives may be due to materno-foetal immune reactions. In 9 patients with pre-eclamplsia, complement levels showed a wider scatter and a significantly higher C3 level than in normal pregnancy. Conversion of C3 to C3i was found in 2 of these patients.

MeSH Terms
Complement C3/analysis Complement C4/analysis Complement C6/analysis Complement C7/analysis Complement System Proteins/analysis Contraceptives, Oral/pharmacology Female Humans Pre-Eclampsia/immunology Pregnancy
Chemicals
Complement C3 Complement C4 Complement C6 Complement C7 Contraceptives, Oral Complement System Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tedder R S
Nelson M
Eisen V
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24 references, click to expand
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Article Info
Journal
British journal of experimental pathology
Abbr.
Br J Exp Pathol
ISSN
0007-1021
Published
1975-10-00
Pages
389-95
Language
English
Region
England
NLM ID
0372543
PMCID
PMC2072786
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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