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PMID: 12151224 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Unsafe SETs: histone lysine methyltransferases and cancer.

Trends in biochemical sciences ·Vol. 27 ·No. 8 ·2002-08-00 ·Pages 396-402

Schneider R, Bannister AJ, Kouzarides T

Abstract

Enzymes that covalently modify histones control many cellular processes by affecting gene expression. A new class of these enzymes is the histone lysine methyltransferase family, whose catalytic activity lies within a conserved domain, the SET domain. This article surveys the evidence for a connection between SET-domain-containing proteins and cancer. It proposes that deregulation of SET-domain function has an important role in carcinogenesis.

MeSH Terms
Amino Acid Sequence Animals Carrier Proteins/genetics,metabolism DNA-Binding Proteins/genetics,metabolism Histone Methyltransferases Histone-Lysine N-Methyltransferase/genetics,metabolism Humans Intracellular Signaling Peptides and Proteins Methyltransferases/genetics,metabolism Mice Molecular Sequence Data Neoplasms/metabolism,physiopathology Nuclear Proteins/genetics,metabolism Protein Structure, Tertiary Retinoblastoma Protein/metabolism Saccharomyces cerevisiae Proteins/genetics,metabolism Transcription Factors/genetics,metabolism
Chemicals
Carrier Proteins DNA-Binding Proteins Intracellular Signaling Peptides and Proteins Nuclear Proteins Retinoblastoma Protein Saccharomyces cerevisiae Proteins Transcription Factors Histone Methyltransferases Methyltransferases SU(VAR)3-9 Set2 protein, S cerevisiae Histone-Lysine N-Methyltransferase NSD1 protein, human Nsd1 protein, mouse PRDM2 protein, human SET1 protein, S cerevisiae
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Schneider Robert
Wellcome/Cancer Research UK Institute and Department of Pathology, Tennis Court Road, Cambridge, UK CB2 1QR.
Bannister Andrew J
Kouzarides Tony
Article Info
Journal
Trends in biochemical sciences
Abbr.
Trends Biochem Sci
ISSN
0968-0004
Published
2002-08-00
Pages
396-402
Language
English
Region
England
NLM ID
7610674
Subset
IM
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