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PMID: 12174790 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Haptoglobin genotypes are not associated with resistance to severe malaria in The Gambia.

Transactions of the Royal Society of Tropical Medicine and Hygiene ·Vol. 96 ·No. 3 ·2002-00-00 ·Pages 327-8

Aucan C, Walley AJ, Greenwood BM, Hill AV

Abstract

The influence of haptoglobin polymorphisms on severe malaria occurrence was assessed in 1183 individuals from The Gambia. No significant association was found between severe malaria and either haptoglobin genotypes or phenotypes. The advantages of using a deoxyribonucleic acid-based haptoglobin typing method are discussed.

MeSH Terms

Case-Control Studies Gambia Gene Frequency Genetic Predisposition to Disease Genotype Haptoglobins/genetics Humans Immunity, Innate/genetics Malaria, Falciparum/genetics,immunology Polymorphism, Genetic

Chemicals

Haptoglobins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Aucan Christophe

Wellcome Trust Centre For Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK. [email protected]

Walley Andrew J

Greenwood Brian M

Hill Adrian V S

Article Info

Journal

Transactions of the Royal Society of Tropical Medicine and Hygiene

Abbr.

Trans R Soc Trop Med Hyg

ISSN

0035-9203

DOI

10.1016/s0035-9203(02)90114-8

[email protected]

Published

2002-00-00

Pages

327-8

Language

English

Region

England

NLM ID

7506129

Subset

Corrections

CommentIn

PMID: 12886791

CommentIn

PMID: 12886818

External Links

PubMed source DOI: 10.1016/s0035-9203(02)90114-8 View journal details

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Haptoglobin genotypes are not associated with resistance to severe malaria in The Gambia.

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