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PMID: 12196580 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Purinergic and muscarinic modulation of the cell cycle and calcium signaling in the chick retinal ventricular zone.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 22 ·No. 17 ·2002-09-01 ·Pages 7569-79

Pearson R, Catsicas M, Becker D, Mobbs P

Abstract

Spontaneous calcium transients occur in the ventricular zone of the chick retina and result from the endogenous release of neurotransmitters in the absence of action potentials. Calcium transients resulting from the activation of purinergic and muscarinic receptors occur in a mixed population of interphase and mitotic cells, whereas those produced by ionotropic GABA and glutamate receptors are mostly restricted to the interphase population, the GABA responses primarily coming from cells that express the neuronal marker TuJ-1. Muscarinic and purinergic receptors can act respectively as a brake and an accelerator on mitosis, whereas GABA and glutamate receptors are without effect. Our results suggest that the balance between muscarinic and purinergic activation acts to control the rate of retinal proliferation in early development.

MeSH Terms
Aniline Compounds Animals Benzimidazoles Biological Clocks/drug effects Calcium/metabolism Calcium Channel Blockers/pharmacology Calcium Signaling/drug effects,physiology Cell Cycle/drug effects,physiology Cell Division/drug effects,physiology Chick Embryo Cholinergic Agonists Excitatory Amino Acid Agonists/pharmacology Fluorescent Dyes In Vitro Techniques Intracellular Fluid/metabolism Microscopy, Confocal Mitosis/physiology Muscarinic Antagonists/pharmacology Neurotransmitter Agents/metabolism Purinergic Agonists Receptors, Muscarinic/drug effects,metabolism Receptors, Purinergic/metabolism Retina/cytology,drug effects,embryology,metabolism Suramin/pharmacology Uridine Triphosphate/pharmacology Xanthenes
Chemicals
Aniline Compounds Benzimidazoles Calcium Channel Blockers Cholinergic Agonists Excitatory Amino Acid Agonists Fluo 4 Fluorescent Dyes Muscarinic Antagonists Neurotransmitter Agents Purinergic Agonists Receptors, Muscarinic Receptors, Purinergic Xanthenes Suramin bisbenzimide ethoxide trihydrochloride Calcium Uridine Triphosphate
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Pearson Rachel
Department of Physiology, University College London, London WC1E 6BT, United Kingdom.
Catsicas Marina
Becker David
Mobbs Peter
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
Published
2002-09-01
Pages
7569-79
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6757998
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source PMC Full Text View journal details
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