Home LiteratureArticle Details
PMID: 12241064 Published · ppublish English Journal Article

Metabolomics and machine learning: explanatory analysis of complex metabolome data using genetic programming to produce simple, robust rules.

Molecular biology reports ·Vol. 29 ·No. 1-2 ·2002-00-00 ·Pages 237-41

Kell DB

Abstract

暂无摘要

MeSH Terms
Animals Gene Expression Profiling Genes, Plant Multivariate Analysis Organisms, Genetically Modified Plants/metabolism Salicylic Acid/metabolism Software
Chemicals
Salicylic Acid
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kell Douglas B
Institute of Biological Sciences, University of Wales, Aberystwyth, UK. [email protected]
References (35)
35 references, click to expand
  1. Gene discovery via metabolic profiling.
    Curr Opin Biotechnol. 2001 Apr;12(2):135-8 PMID: 11287226
  2. Automated mode-of-action detection by metabolic profiling.
    Biochem Biophys Res Commun. 2001 Aug 10;286(1):150-5 PMID: 11485321
  3. Metabolic profiling: a Rosetta Stone for genomics?
    Curr Opin Plant Biol. 1999 Apr;2(2):83-5 PMID: 10322197
  4. Compromising early salicylic acid accumulation delays the hypersensitive response and increases viral dispersal during lesion establishment in TMV-infected tobacco.
    Plant J. 1997 Nov;12(5):1113-26 PMID: 9418052
  5. Functional discovery via a compendium of expression profiles.
    Cell. 2000 Jul 7;102(1):109-26 PMID: 10929718
  6. Microarrays and toxicology: the advent of toxicogenomics.
    Mol Carcinog. 1999 Mar;24(3):153-9 PMID: 10204799
  7. Conceptual modelling of genomic information.
    Bioinformatics. 2000 Jun;16(6):548-57 PMID: 10980152
  8. Visualizing plant metabolomic correlation networks using clique-metabolite matrices.
    Bioinformatics. 2001 Dec;17(12):1198-208 PMID: 11751228
  9. Metabolomics--the link between genotypes and phenotypes.
    Plant Mol Biol. 2002 Jan;48(1-2):155-71 PMID: 11860207
  10. Genomic biology.
    Cell. 2000 Jan 7;100(1):169-83 PMID: 10647941
  11. Metabolite profiling for plant functional genomics.
    Nat Biotechnol. 2000 Nov;18(11):1157-61 PMID: 11062433
  12. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data.
    Xenobiotica. 1999 Nov;29(11):1181-9 PMID: 10598751
  13. Increasing the flux in metabolic pathways: A metabolic control analysis perspective
    Biotechnol Bioeng. 1998 Apr 5;58(2-3):121-4 PMID: 10191380
  14. Protein microarrays: prospects and problems.
    Chem Biol. 2001 Feb;8(2):105-15 PMID: 11251285
  15. Hydrogen peroxide does not function downstream of salicylic acid in the induction of PR protein expression.
    Plant J. 1995 Aug;8(2):235-45 PMID: 7670505
  16. Genomic expression programs in the response of yeast cells to environmental changes.
    Mol Biol Cell. 2000 Dec;11(12):4241-57 PMID: 11102521
  17. Can we discover novel pathways using metabolomic analysis?
    Curr Opin Biotechnol. 2002 Apr;13(2):156-60 PMID: 11950569
  18. Analysis of proteins and proteomes by mass spectrometry.
    Annu Rev Biochem. 2001;70:437-73 PMID: 11395414
  19. On the optimization of classes for the assignment of unidentified reading frames in functional genomics programmes: the need for machine learning.
    Trends Biotechnol. 2000 Mar;18(3):93-8 PMID: 10675895
  20. Rapid and quantitative detection of the microbial spoilage of meat by fourier transform infrared spectroscopy and machine learning.
    Appl Environ Microbiol. 2002 Jun;68(6):2822-8 PMID: 12039738
  21. High-density microarrays for gene expression analysis.
    Cytometry. 2001 Apr 1;43(4):229-38 PMID: 11260590
  22. Integrated studies on plant biology using multiparallel techniques.
    Curr Opin Biotechnol. 2001 Feb;12(1):82-6 PMID: 11167078
  23. Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway.
    FEBS Lett. 2001 Jul 6;500(3):169-71 PMID: 11445079
  24. Metabolic profiling of genetic disorders: a multitissue (1)H nuclear magnetic resonance spectroscopic and pattern recognition study into dystrophic tissue.
    Anal Biochem. 2001 Jun 1;293(1):16-21 PMID: 11373073
  25. What bio technologists knew all along...?
    J Theor Biol. 1996 Oct 7;182(3):411-20 PMID: 8944175
  26. Exploring the metabolic and genetic control of gene expression on a genomic scale.
    Science. 1997 Oct 24;278(5338):680-6 PMID: 9381177
  27. A loss of resistance to avirulent bacterial pathogens in tobacco is associated with the attenuation of a salicylic acid-potentiated oxidative burst.
    Plant J. 2000 Sep;23(5):609-21 PMID: 10972887
  28. A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations.
    Nat Biotechnol. 2001 Jan;19(1):45-50 PMID: 11135551
  29. The principles and practice of toxigenomics: applications and opportunities.
    Toxicol Sci. 2000 Apr;54(2):277-83 PMID: 10774809
  30. Towards a truly integrative biology through the functional genomics of yeast.
    Curr Opin Biotechnol. 2001 Feb;12(1):87-91 PMID: 11167079
  31. Genomic computing. Explanatory analysis of plant expression profiling data using machine learning.
    Plant Physiol. 2001 Jul;126(3):943-51 PMID: 11457944
  32. Functional genomics: learning to think about gene expression data.
    Curr Biol. 1999 May 6;9(9):R338-41 PMID: 10322108
  33. Functional genomics: high-throughput mRNA, protein, and metabolite analyses.
    Metab Eng. 2002 Jan;4(1):98-106 PMID: 11800579
  34. Whole-cell simulation: a grand challenge of the 21st century.
    Trends Biotechnol. 2001 Jun;19(6):205-10 PMID: 11356281
  35. Monitoring of complex industrial bioprocesses for metabolite concentrations using modern spectroscopies and machine learning: application to gibberellic acid production.
    Biotechnol Bioeng. 2002 Jun 5;78(5):527-38 PMID: 12115122
Article Info
Journal
Molecular biology reports
Abbr.
Mol Biol Rep
ISSN
0301-4851
DOI
10.1023/a:1020342216314
Email
[email protected]
Published
2002-00-00
Pages
237-41
Language
English
Region
Netherlands
NLM ID
0403234
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1020342216314 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2