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PMID: 12324680 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Chronic obstructive pulmonary disease * 3: Experimental animal models of pulmonary emphysema.

Thorax ·Vol. 57 ·No. 10 ·2002-10-00 ·Pages 908-14

Mahadeva R, Shapiro SD

Abstract

The use of genetically manipulated mice together with traditional animal studies are steadily increasing our knowledge of the factors important in determining alveolar formation and destruction in emphysema. A review of the animal models used to study emphysema is presented.

MeSH Terms
Animals Disease Models, Animal Gene Targeting Genetic Engineering Mice Mice, Mutant Strains Mice, Transgenic Mutation/genetics Pulmonary Disease, Chronic Obstructive/etiology Pulmonary Emphysema/chemically induced,etiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mahadeva R
Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, UK. [email protected]
Shapiro S D
References (65)
65 references, click to expand
  1. EXPERIMENTAL EMPHYSEMA: ITS PRODUCTION WITH PAPAIN IN NORMAL AND SILICOTIC RATS.
    Arch Environ Health. 1965 Jul;11:50-8 PMID: 14312390
  2. Impaired distal airway development in mice lacking elastin.
    Am J Respir Cell Mol Biol. 2000 Sep;23(3):320-6 PMID: 10970822
  3. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema.
    J Clin Invest. 2000 Nov;106(9):1081-93 PMID: 11067861
  4. Retinoic acid receptor-beta: an endogenous inhibitor of the perinatal formation of pulmonary alveoli.
    Physiol Genomics. 2000 Nov 9;4(1):51-7 PMID: 11074013
  5. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema.
    J Clin Invest. 2000 Dec;106(11):1311-9 PMID: 11104784
  6. Interferon gamma induction of pulmonary emphysema in the adult murine lung.
    J Exp Med. 2000 Dec 4;192(11):1587-600 PMID: 11104801
  7. Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis.
    Dev Biol. 2001 Apr 1;232(1):204-18 PMID: 11254358
  8. Identification of a novel lipopolysaccharide-inducible gene with key features of both A kinase anchor proteins and chs1/beige proteins.
    J Immunol. 2001 Apr 1;166(7):4586-95 PMID: 11254716
  9. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema.
    Am J Respir Crit Care Med. 2001 Mar;163(3 Pt 1):737-44 PMID: 11254533
  10. Surfactant protein D regulates NF-kappa B and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways.
    J Immunol. 2001 Jun 15;166(12):7514-9 PMID: 11390505
  11. The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis.
    Development. 1999 Dec;126(24):5771-83 PMID: 10572052
  12. The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency.
    Nat Genet. 1999 Nov;23(3):329-32 PMID: 10610180
  13. The challenge of providing better care for patients with chronic obstructive pulmonary disease: the poor relation of airways obstruction?
    Thorax. 2000 Jan;55(1):78-82 PMID: 10607806
  14. Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life.
    Am J Respir Cell Mol Biol. 2000 Jan;22(1):26-33 PMID: 10615062
  15. Acute cigarette smoke-induced connective tissue breakdown is mediated by neutrophils and prevented by alpha1-antitrypsin.
    Am J Respir Cell Mol Biol. 2000 Feb;22(2):244-52 PMID: 10657946
  16. Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung.
    Am J Respir Cell Mol Biol. 2000 Mar;22(3):289-95 PMID: 10696065
  17. The molecular basis of lung morphogenesis.
    Mech Dev. 2000 Mar 15;92(1):55-81 PMID: 10704888
  18. Mice bearing deletions of retinoic acid receptors demonstrate reduced lung elastin and alveolar numbers.
    Am J Respir Cell Mol Biol. 2000 Aug;23(2):162-7 PMID: 10919981
  19. New insights into the assembly of extracellular microfibrils from the analysis of the fibrillin 1 mutation in the tight skin mouse.
    J Cell Biol. 2000 Aug 7;150(3):667-80 PMID: 10931876
  20. Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor.
    Dev Biol. 2001 Jul 15;235(2):489-506 PMID: 11437453
  21. End-stage chronic obstructive pulmonary disease: the cigarette is burned out but inflammation rages on.
    Am J Respir Crit Care Med. 2001 Aug 1;164(3):339-40 PMID: 11500330
  22. Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3).
    J Clin Invest. 2001 Sep;108(6):817-29 PMID: 11560951
  23. Alveolar macrophage deficiency in osteopetrotic mice deficient in macrophage colony-stimulating factor is spontaneously corrected with age and associated with matrix metalloproteinase expression and emphysema.
    Blood. 2001 Nov 1;98(9):2845-52 PMID: 11675359
  24. The importance of ultramicroscopic emphysema in cigarette smoke-induced lung disease.
    Lung. 2001;179(2):71-81 PMID: 11733850
  25. Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response.
    Am J Respir Cell Mol Biol. 2002 Jan;26(1):52-7 PMID: 11751203
  26. Severity of elastase-induced emphysema is decreased in tumor necrosis factor-alpha and interleukin-1beta receptor-deficient mice.
    Lab Invest. 2002 Jan;82(1):79-85 PMID: 11796828
  27. Fibulin-5/DANCE is essential for elastogenesis in vivo.
    Nature. 2002 Jan 10;415(6868):171-5 PMID: 11805835
  28. Pulmonary intravascular leukocyte sequestration. A potential mechanism of lung injury.
    Am Rev Respir Dis. 1974 May;109(5):502-9 PMID: 4207271
  29. Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton.
    Am J Pathol. 1976 Mar;82(3):493-512 PMID: 176891
  30. The induction of emphysema with elastase. II. Changes in connective tissue.
    Lab Invest. 1976 Apr;34(4):372-80 PMID: 177809
  31. Emphysema-like changes in the lungs of the blotchy mouse.
    Am Rev Respir Dis. 1976 Jun;113(6):787-97 PMID: 937819
  32. The effect of lathyrogens on the evolution of elastase-induced emphysema.
    Am Rev Respir Dis. 1980 Sep;122(3):453-60 PMID: 6106444
  33. Chemotactic activity of elastin-derived peptides.
    J Clin Invest. 1980 Oct;66(4):859-62 PMID: 6903189
  34. Elastin fragments attract macrophage precursors to diseased sites in pulmonary emphysema.
    Science. 1981 May 22;212(4497):925-7 PMID: 7233186
  35. Lung fibrosis and emphysema: divergent responses to a common injury?
    Science. 1982 Jul 23;217(4557):359-60 PMID: 7089570
  36. Hereditary emphysema in the tight-skin mouse. Evaluation of pathogenesis.
    Am Rev Respir Dis. 1984 May;129(5):850-5 PMID: 6562869
  37. Animal models of emphysema.
    Am Rev Respir Dis. 1986 Jan;133(1):149-69 PMID: 3510579
  38. Structural crosslinking of lung connective tissue collagen in the blotchy mouse.
    Exp Lung Res. 1987;12(2):109-17 PMID: 3569165
  39. Cadmium-chloride-induced air-space enlargement with interstitial pulmonary fibrosis is not associated with destruction of lung elastin. Implications for the pathogenesis of human emphysema.
    Am Rev Respir Dis. 1988 Apr;137(4):918-23 PMID: 3355000
  40. Cigarette smoke causes physiologic and morphologic changes of emphysema in the guinea pig.
    Am Rev Respir Dis. 1990 Dec;142(6 Pt 1):1422-8 PMID: 2252262
  41. Prevention of leucocyte elastase-induced emphysema in mice by heparin fragments.
    Eur Respir J. 1991 Sep;4(8):1004-9 PMID: 1783073
  42. Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema.
    Cell. 1992 Dec 11;71(6):955-61 PMID: 1458541
  43. The pallid mouse. A model of genetic alpha 1-antitrypsin deficiency.
    Lab Invest. 1993 Feb;68(2):233-41 PMID: 8441253
  44. Mutations in the murine homologue of the Menkes gene in dappled and blotchy mice.
    Nat Genet. 1994 Apr;6(4):374-8 PMID: 8054977
  45. Pallid mice with genetic emphysema. Neutrophil elastase burden and elastin loss occur without alteration in the bronchoalveolar lavage cell population.
    Lab Invest. 1995 Jul;73(1):40-7 PMID: 7603039
  46. Modulation of airspace enlargement in elastase-induced emphysema by intratracheal instillment of hyaluronidase and hyaluronic acid.
    Exp Lung Res. 1995 May-Jun;21(3):423-36 PMID: 7621778
  47. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity.
    Nat Med. 1995 Oct;1(10):1024-8 PMID: 7489357
  48. Effect of oxidant air pollutants on the respiratory system: insights from experimental animal research.
    Eur Respir J. 1995 Aug;8(8):1357-71 PMID: 7489804
  49. Mineral dusts cause elastin and collagen breakdown in the rat lung: a potential mechanism of dust-induced emphysema.
    Am J Respir Crit Care Med. 1996 Feb;153(2):644-9 PMID: 8564112
  50. PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis.
    Cell. 1996 Jun 14;85(6):863-73 PMID: 8681381
  51. A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation.
    Genome Res. 1996 Apr;6(4):300-13 PMID: 8723723
  52. Compound mutants for retinoic acid receptor (RAR) beta and RAR alpha 1 reveal developmental functions for multiple RAR beta isoforms.
    Mech Dev. 1996 Mar;55(1):33-44 PMID: 8734497
  53. Identification of the homologous beige and Chediak-Higashi syndrome genes.
    Nature. 1996 Jul 18;382(6588):262-5 PMID: 8717042
  54. A scanning electron microscopic investigation of genetic emphysema in tight-skin, pallid, and beige mice, three different C57 BL/6J mutants.
    Lab Invest. 1996 Feb;74(2):353-62 PMID: 8780155
  55. Mighty mice: transgenic technology "knocks out" questions of matrix metalloproteinase function.
    Matrix Biol. 1997 Mar;15(8-9):527-33 PMID: 9138285
  56. Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats.
    Nat Med. 1997 Jun;3(6):675-7 PMID: 9176496
  57. Further investigation of the use of intratracheally administered hyaluronic acid to ameliorate elastase-induced emphysema.
    Exp Lung Res. 1997 May-Jun;23(3):229-44 PMID: 9184790
  58. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice.
    Science. 1997 Sep 26;277(5334):2002-4 PMID: 9302297
  59. Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development.
    Development. 1997 Oct;124(20):3943-53 PMID: 9374392
  60. Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes.
    J Clin Invest. 1997 Nov 15;100(10):2501-11 PMID: 9366564
  61. FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung.
    Development. 1998 Sep;125(18):3615-23 PMID: 9716527
  62. VEGF is required for growth and survival in neonatal mice.
    Development. 1999 Mar;126(6):1149-59 PMID: 10021335
  63. Emphysematous lesions, inflammation, and fibrosis in the lungs of transgenic mice overexpressing platelet-derived growth factor.
    Am J Pathol. 1999 Jun;154(6):1763-75 PMID: 10362801
  64. Ultrastructure of lung elastin and collagen in mouse models of spontaneous emphysema.
    Matrix Biol. 1999 Aug;18(4):357-60 PMID: 10517182
  65. Pulmonary emphysema with special reference to vascular changes.
    Am Rev Respir Dis. 1959 Jul;80(1, Part 2):67-93 PMID: 13670406
Article Info
Journal
Thorax
Abbr.
Thorax
ISSN
0040-6376
DOI
10.1136/thorax.57.10.908
Email
[email protected]
Published
2002-10-00
Pages
908-14
Language
English
Region
England
NLM ID
0417353
PMCID
PMC1746206
Subset
IM
External Links
PubMed source DOI: 10.1136/thorax.57.10.908 PMC Full Text View journal details
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