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PMID: 12368867 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.

Nature ·Vol. 419 ·No. 6906 ·2002-10-03 ·Pages 527-31

Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D, Mungall K, Bowman S, Atkin R, Baker S, Barron A, Brooks K, Buckee CO, Burrows C, Cherevach I, Chillingworth C, Chillingworth T, Christodoulou Z, Clark L, Clark R, Corton C, Cronin A, Davies R, Davis P, Dear P, Dearden F, Doggett J, Feltwell T, Goble A, Goodhead I, Gwilliam R, Hamlin N, Hance Z, Harper D, Hauser H, Hornsby T, Holroyd S, Horrocks P, Humphray S, Jagels K, James KD, Johnson D, Kerhornou A, Knights A, Konfortov B, Kyes S, Larke N, Lawson D, Lennard N, Line A, Maddison M, McLean J, Mooney P, Moule S, Murphy L, Oliver K, Ormond D, Price C, Quail MA, Rabbinowitsch E, Rajandream MA, Rutter S, Rutherford KM, Sanders M, Simmonds M, Seeger K, Sharp S, Smith R, Squares R, Squares S, Stevens K, Taylor K, Tivey A, Unwin L, Whitehead S, Woodward J, Sulston JE, Craig A, Newbold C, Barrell BG

Abstract

Since the sequencing of the first two chromosomes of the malaria parasite, Plasmodium falciparum, there has been a concerted effort to sequence and assemble the entire genome of this organism. Here we report the sequence of chromosomes 1, 3-9 and 13 of P. falciparum clone 3D7--these chromosomes account for approximately 55% of the total genome. We describe the methods used to map, sequence and annotate these chromosomes. By comparing our assemblies with the optical map, we indicate the completeness of the resulting sequence. During annotation, we assign Gene Ontology terms to the predicted gene products, and observe clustering of some malaria-specific terms to specific chromosomes. We identify a highly conserved sequence element found in the intergenic region of internal var genes that is not associated with their telomeric counterparts.

MeSH Terms

Animals Base Sequence Chromosomes DNA, Protozoan Genes, Protozoan Genome, Protozoan Molecular Sequence Data Multigene Family Plasmodium falciparum/genetics Proteome Protozoan Proteins/genetics Sequence Analysis, DNA

Chemicals

DNA, Protozoan Proteome Protozoan Proteins

Authors & Affiliations

80 authors, click to expand affiliations / ORCID

Hall N

The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. [email protected]

Pain A

Berriman M

Churcher C

Harris B

Harris D

Mungall K

Bowman S

Atkin R

Baker S

Barron A

Brooks K

Buckee C O

Burrows C

Cherevach I

Chillingworth C

Chillingworth T

Christodoulou Z

Clark L

Clark R

Corton C

Cronin A

Davies R

Davis P

Dear P

Dearden F

Doggett J

Feltwell T

Goble A

Goodhead I

Gwilliam R

Hamlin N

Hance Z

Harper D

Hauser H

Hornsby T

Holroyd S

Horrocks P

Humphray S

Jagels K

James K D

Johnson D

Kerhornou A

Knights A

Konfortov B

Kyes S

Larke N

Lawson D

Lennard N

Line A

Maddison M

McLean J

Mooney P

Moule S

Murphy L

Oliver K

Ormond D

Price C

Quail M A

Rabbinowitsch E

Rajandream M-A

Rutter S

Rutherford K M

Sanders M

Simmonds M

Seeger K

Sharp S

Smith R

Squares R

Squares S

Stevens K

Taylor K

Tivey A

Unwin L

Whitehead S

Woodward J

Sulston J E

Craig A

Newbold C

Barrell B G

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/nature01095

[email protected]

Published

2002-10-03

Pages

527-31

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

AL844501, AL844502, AL844503, AL844504, AL844505, AL844506, AL844507, AL844508, AL844509

Corrections

CommentIn

PMID: 12368831

CommentIn

PMID: 12368861

CommentIn

PMID: 12368862

External Links

PubMed source DOI: 10.1038/nature01095 View journal details

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Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.

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