Transcription activation: unveiling the essential nature of TFIID.

Current biology : CB ·Vol. 12 ·No. 18 ·2002-09-17 ·Pages R620-2

Chen BS, Hampsey M

Abstract

The TAF subunits of TFIID mediate activation of subsets of the eukaryotic genome. Recent results demonstrate that TFIID is recruited to promoters in an activator-specific manner involving functional interaction between upstream regulatory elements and the core promoter, thereby coordinating the expression of distinct sets of genes.

MeSH Terms

Animals Humans Macromolecular Substances Models, Biological Protein Subunits TATA-Binding Protein Associated Factors/chemistry,genetics,physiology Transcription Factor TFIID/chemistry,genetics,physiology Transcriptional Activation

Chemicals

Macromolecular Substances Protein Subunits TATA-Binding Protein Associated Factors Transcription Factor TFIID

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Chen Bo-Shiun

Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

Hampsey Michael

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(02)01134-x

Published

2002-09-17

Pages

R620-2

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(02)01134-x View journal details

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