Home LiteratureArticle Details
PMID: 12374931 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Somatic cell nuclear transfer.

Nature ·Vol. 419 ·No. 6907 ·2002-10-10 ·Pages 583-6

Wilmut I, Beaujean N, de Sousa PA, Dinnyes A, King TJ, Paterson LA, Wells DN, Young LE

Abstract

Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.

MeSH Terms
Animals Cattle Cell Cycle Cell Differentiation Cloning, Organism Embryonic and Fetal Development Fetal Death Forecasting Gene Expression Regulation, Developmental Goats Mice Nuclear Transfer Techniques Oocytes/cytology Ploidies Sheep Swine
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Wilmut I
Roslin Institute, Roslin, Midlothian EH25 9PS, UK. [email protected]
Beaujean N
de Sousa P A
Dinnyes A
King T J
Paterson L A
Wells D N
Young L E
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/nature01079
Email
[email protected]
Published
2002-10-10
Pages
583-6
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/nature01079 View journal details
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