Cesium induced rectifications in frog myelinated fibres.
Voltage clamp experiments done on nodes of Ranvier show that external application of Cesium blocks the inward but not the outward potassium currents. Internal application of Cs ions reduces the outward K-current and the inward K-current is not affected. These results support the hypotheses that K ions cross th- K-channel after dehydration at superficial sites where competition may occur with Cs-ions.
7 references, click to expand
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Potassium channels in myelinated nerve. Selective permeability to small cations.J Gen Physiol. 1973 Jun;61(6):669-86 PMID: 4541077
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[Effect of tetrodotoxin and tertaethylammonium chloride on the inside of the membrane of Ranvier's node in Xenopus laevis].Pflugers Arch. 1969;313(4):361-80 PMID: 4188682
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Increase of sodium concentration near the inner surface of the nodal membrane.Pflugers Arch. 1970;317(4):287-302 PMID: 5463657
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A new voltage clamp method for Ranvier nodes.Pflugers Arch. 1969;309(2):176-92 PMID: 5815327
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The permeability of the sodium channel to metal cations in myelinated nerve.J Gen Physiol. 1972 Jun;59(6):637-58 PMID: 5025743
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Negative conductance caused by entry of sodium and cesium ions into the potassium channels of squid axons.J Gen Physiol. 1972 Nov;60(5):588-608 PMID: 4644327
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Voltage clamp experiments on internally perfused giant axons.J Physiol. 1965 Oct;180(4):788-820 PMID: 5880363
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