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PMID: 12407441 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials.

Neoplasia (New York, N.Y.) ·Vol. 4 ·No. 6 ·2002-00-00 ·Pages 480-5

Koutcher JA, Hu X, Xu S, Gade TP, Leeds N, Zhou XJ, Zagzag D, Holland EC

Abstract

Magnetic resonance imaging (MRI) has been utilized for screening and detecting brain tumors in mice based upon their imaging characteristics appearance and their pattern of enhancement. Imaging of these tumors reveals many similarities to those observed in humans with identical pathology. Specifically, high-grade murine gliomas have histologic characteristics of glioblastoma multiforme (GBM) with contrast enhancement after intravenous administration of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA), implying disruption of the blood-brain barrier in these tumors. In contrast, low-grade murine oligodendrogliomas do not reveal contrast enhancement, similar to human tumors. MRI can be used to identify mice with brain neoplasms as inclusion criteria in preclinical trials.

MeSH Terms
Animals Brain Neoplasms/diagnosis,diagnostic imaging,pathology Disease Models, Animal ErbB Receptors/genetics,metabolism Gadolinium DTPA Glioblastoma/diagnosis,diagnostic imaging,pathology Humans Magnetic Resonance Imaging/methods Mice Mice, Transgenic Protein Serine-Threonine Kinases Proto-Oncogene Proteins/metabolism Proto-Oncogene Proteins c-akt Radiography Retroviridae/genetics ras Proteins/metabolism
Chemicals
Proto-Oncogene Proteins ErbB Receptors Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-akt ras Proteins Gadolinium DTPA
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Koutcher Jason A
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. [email protected]
Hu Xiaoyi
Xu Su
Gade Terence P F
Leeds Norman
Zhou Xiaohong Joe
Zagzag David
Holland Eric C
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Article Info
Journal
Neoplasia (New York, N.Y.)
Abbr.
Neoplasia
ISSN
1522-8002
DOI
10.1038/sj.neo.7900269
Email
[email protected]
Published
2002-00-00
Pages
480-5
Language
English
Region
United States
NLM ID
100886622
PMCID
PMC1503661
Subset
IM
Grants
NCI NIH HHS · CA-08748 · United States
NCI NIH HHS · P30 CA008748 · United States
NCI NIH HHS · U01 CA894314-1 · United States
NCI NIH HHS · R24CA83084 · United States
NCI NIH HHS · R24 CA083084 · United States
External Links
PubMed source DOI: 10.1038/sj.neo.7900269 PMC Full Text
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