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PMID: 12429530 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Enhanced overexpression of an HIF-1/hypoxia-related protein in cancer cells.

Environmental health perspectives ·Vol. 110 Suppl 5 ·2002-10-00 ·Pages 783-8

Cangul H, Salnikow K, Yee H, Zagzag D, Commes T, Costa M

Abstract

Cap43 is a protein whose RNA is induced under conditions of severe hypoxia or prolonged elevations of intracellular calcium. Additionally, Ni and Co also induce Cap43 because they produce a state of hypoxia in cells. Cap43 protein is expressed at low levels in normal tissues; however, in a variety of cancers, including lung, brain, melanoma, liver, prostate, breast, and renal cancers, Cap43 protein is overexpressed in cancer cells. The low level of expression of Cap43 in some normal tissues compared with their cancerous counterparts, combined with the high stability of Cap43 protein and mRNA, makes the Cap43 gene a new, important cancer marker. We hypothesize that the mechanism of Cap43 overexpression in cancer cells involves a state of hypoxia characteristic of cancer cells where the Cap43 protein becomes a signature for this hypoxic state.

MeSH Terms
Biomarkers, Tumor/analysis Blotting, Northern Cell Cycle Proteins Cell Hypoxia Colonic Neoplasms/genetics,physiopathology DNA-Binding Proteins/pharmacology Gene Expression Regulation Humans Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Intracellular Signaling Peptides and Proteins Lung Neoplasms/genetics,physiopathology Nuclear Proteins/pharmacology Protein Biosynthesis Proteins RNA, Messenger/analysis Transcription Factors Tumor Cells, Cultured
Chemicals
Biomarkers, Tumor Cell Cycle Proteins DNA-Binding Proteins HIF1A protein, human Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Intracellular Signaling Peptides and Proteins N-myc downstream-regulated gene 1 protein Nuclear Proteins Proteins RNA, Messenger Transcription Factors
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Cangul Hakan
Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Salnikow Konstantin
Yee Herman
Zagzag David
Commes Therese
Costa Max
References (16)
16 references, click to expand
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Article Info
Journal
Environmental health perspectives
Abbr.
Environ Health Perspect
ISSN
0091-6765
DOI
10.1289/ehp.02110s5783
Published
2002-10-00
Pages
783-8
Language
English
Region
United States
NLM ID
0330411
PMCID
PMC1241245
Subset
IM
Grants
NIEHS NIH HHS · ES 00260 · United States
NIEHS NIH HHS · ES 05512 · United States
NIEHS NIH HHS · ES 10344 · United States
External Links
PubMed source DOI: 10.1289/ehp.02110s5783 PMC Full Text View journal details
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