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PMID: 12455968 Published · ppublish English Journal Article Review

Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress.

Eukaryotic cell ·Vol. 1 ·No. 1 ·2002-02-00 ·Pages 22-32

Hinnebusch AG, Natarajan K

Abstract

暂无摘要

MeSH Terms
Animals DNA-Binding Proteins/metabolism Eukaryotic Cells/cytology,physiology Gene Expression Regulation Mammals Protein Biosynthesis Protein Kinases/genetics,metabolism Protein Serine-Threonine Kinases Saccharomyces cerevisiae Proteins/genetics,metabolism Transcription, Genetic
Chemicals
DNA-Binding Proteins Saccharomyces cerevisiae Proteins Protein Kinases GCN2 protein, S cerevisiae Protein Serine-Threonine Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hinnebusch Alan G
Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA. [email protected]
Natarajan Krishnamurthy
References (91)
91 references, click to expand
  1. Remodeling of yeast genome expression in response to environmental changes.
    Mol Biol Cell. 2001 Feb;12(2):323-37 PMID: 11179418
  2. The proteasome regulates the UV-induced activation of the AP-1-like transcription factor Gcn4.
    Genes Dev. 2001 Jan 15;15(2):128-33 PMID: 11157770
  3. TOR modulates GCN4-dependent expression of genes turned on by nitrogen limitation.
    J Bacteriol. 2001 Apr;183(7):2331-4 PMID: 11244074
  4. The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation.
    EMBO J. 2001 Mar 15;20(6):1425-38 PMID: 11250908
  5. Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase.
    Genes Dev. 2001 May 1;15(9):1078-92 PMID: 11331604
  6. Gcn2 mediates Gcn4 activation in response to glucose stimulation or UV radiation not via GCN4 translation.
    J Biol Chem. 2001 May 18;276(20):16944-51 PMID: 11350978
  7. Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2.
    J Biol Chem. 2001 May 18;276(20):17591-6 PMID: 11350982
  8. Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast.
    Mol Cell Biol. 2001 Jul;21(13):4347-68 PMID: 11390663
  9. Repression of GCN4 mRNA translation by nitrogen starvation in Saccharomyces cerevisiae.
    J Biol Chem. 2001 Jul 13;276(28):25661-71 PMID: 11356835
  10. Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association.
    Nat Genet. 2001 Aug;28(4):327-34 PMID: 11455386
  11. The protein kinase Gcn2p mediates sodium toxicity in yeast.
    J Biol Chem. 2001 Aug 17;276(33):30753-60 PMID: 11408481
  12. Regulated translation initiation controls stress-induced gene expression in mammalian cells.
    Mol Cell. 2000 Nov;6(5):1099-108 PMID: 11106749
  13. Evidence for translational regulation of the activator of general amino acid control in yeast.
    Proc Natl Acad Sci U S A. 1984 Oct;81(20):6442-6 PMID: 6387704
  14. Three regulatory systems control production of glutamine synthetase in Saccharomyces cerevisiae.
    Mol Cell Biol. 1984 Dec;4(12):2767-73 PMID: 6152013
  15. A hierarchy of trans-acting factors modulates translation of an activator of amino acid biosynthetic genes in Saccharomyces cerevisiae.
    Mol Cell Biol. 1985 Sep;5(9):2349-60 PMID: 3915540
  16. The general control of amino acid biosynthetic genes in the yeast Saccharomyces cerevisiae.
    CRC Crit Rev Biochem. 1986;21(3):277-317 PMID: 3536302
  17. Structure of yeast regulatory gene LEU3 and evidence that LEU3 itself is under general amino acid control.
    Nucleic Acids Res. 1987 Jul 10;15(13):5261-73 PMID: 3299266
  18. Multiple global regulators control HIS4 transcription in yeast.
    Science. 1987 Aug 21;237(4817):874-80 PMID: 3303332
  19. Control of enzyme synthesis in the lysine biosynthetic pathway of Saccharomyces cerevisiae. Evidence for a regulatory role of gene LYS14.
    Eur J Biochem. 1988 Jan 15;171(1-2):171-6 PMID: 3123231
  20. Coupling of GCN4 mRNA translational activation with decreased rates of polypeptide chain initiation.
    Cell. 1989 Jun 16;57(6):947-54 PMID: 2661015
  21. BAS1 has a Myb motif and activates HIS4 transcription only in combination with BAS2.
    Science. 1989 Nov 17;246(4932):931-5 PMID: 2683089
  22. Activators and targets.
    Nature. 1990 Jul 26;346(6282):329-31 PMID: 2142753
  23. Mutations that define the optimal half-site for binding yeast GCN4 activator protein and identify an ATF/CREB-like repressor that recognizes similar DNA sites.
    Mol Cell Biol. 1990 Oct;10(10):5077-86 PMID: 2204805
  24. cpc-2, a new locus involved in general control of amino acid synthetic enzymes in Neurospora crassa.
    Curr Genet. 1990 Oct;18(3):211-5 PMID: 2147403
  25. Association of RAP1 binding sites with stringent control of ribosomal protein gene transcription in Saccharomyces cerevisiae.
    Mol Cell Biol. 1991 May;11(5):2723-35 PMID: 2017175
  26. Transcriptional activation of yeast nucleotide biosynthetic gene ADE4 by GCN4.
    J Biol Chem. 1991 Oct 25;266(30):20453-6 PMID: 1939099
  27. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors.
    Nature. 1999 Dec 9;402(6762):689-92 PMID: 10604478
  28. Aromatic amino acid biosynthesis in the yeast Saccharomyces cerevisiae: a model system for the regulation of a eukaryotic biosynthetic pathway.
    Microbiol Rev. 1991 Sep;55(3):349-70 PMID: 1943992
  29. Coregulation of purine and histidine biosynthesis by the transcriptional activators BAS1 and BAS2.
    Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6746-50 PMID: 1495962
  30. Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2.
    Mol Cell Biol. 1993 Aug;13(8):5099-111 PMID: 8336737
  31. Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.
    Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):839-43 PMID: 8302854
  32. Protein kinase A mediates growth-regulated expression of yeast ribosomal protein genes by modulating RAP1 transcriptional activity.
    Mol Cell Biol. 1994 Mar;14(3):1920-8 PMID: 8114723
  33. The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals.
    Cell. 1994 May 6;77(3):381-90 PMID: 8181058
  34. Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA.
    Mol Cell Biol. 1994 Dec;14(12):7920-32 PMID: 7969132
  35. Regulated degradation of the transcription factor Gcn4.
    EMBO J. 1994 Dec 15;13(24):6021-30 PMID: 7813440
  36. GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells.
    EMBO J. 1995 Jul 3;14(13):3184-99 PMID: 7621831
  37. The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids.
    Mol Cell Biol. 1995 Aug;15(8):4497-506 PMID: 7623840
  38. Quantitative monitoring of gene expression patterns with a complementary DNA microarray.
    Science. 1995 Oct 20;270(5235):467-70 PMID: 7569999
  39. Pip2p: a transcriptional regulator of peroxisome proliferation in the yeast Saccharomyces cerevisiae.
    EMBO J. 1996 Jun 17;15(12):2924-34 PMID: 8670793
  40. The ARG11 gene of Saccharomyces cerevisiae encodes a mitochondrial integral membrane protein required for arginine biosynthesis.
    J Biol Chem. 1996 Oct 4;271(40):25011-8 PMID: 8798783
  41. Amino acid and adenine cross-pathway regulation act through the same 5'-TGACTC-3' motif in the yeast HIS7 promoter.
    J Biol Chem. 1996 Nov 22;271(47):29637-43 PMID: 8939895
  42. RNA polymerase II holoenzymes and subcomplexes.
    J Biol Chem. 1998 Oct 23;273(43):27757-60 PMID: 9774381
  43. The transcriptional program of sporulation in budding yeast.
    Science. 1998 Oct 23;282(5389):699-705 PMID: 9784122
  44. Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitation.
    Nat Biotechnol. 1998 Oct;16(10):939-45 PMID: 9788350
  45. Dissecting the regulatory circuitry of a eukaryotic genome.
    Cell. 1998 Nov 25;95(5):717-28 PMID: 9845373
  46. The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease.
    EMBO J. 1998 Dec 1;17(23):6924-31 PMID: 9843498
  47. Activator-specific requirement of yeast mediator proteins for RNA polymerase II transcriptional activation.
    Mol Cell Biol. 1999 Feb;19(2):979-88 PMID: 9891034
  48. Global response of Saccharomyces cerevisiae to an alkylating agent.
    Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1486-91 PMID: 9990050
  49. The WD protein Cpc2p is required for repression of Gcn4 protein activity in yeast in the absence of amino-acid starvation.
    Mol Microbiol. 1999 Feb;31(3):807-22 PMID: 10048025
  50. Detecting patterns of protein distribution and gene expression in silico.
    Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2937-42 PMID: 10077615
  51. An activator binding module of yeast RNA polymerase II holoenzyme.
    Mol Cell Biol. 1999 Apr;19(4):2967-76 PMID: 10082564
  52. Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae.
    Mol Biol Cell. 1999 Apr;10(4):987-1000 PMID: 10198052
  53. Direct analysis of protein complexes using mass spectrometry.
    Nat Biotechnol. 1999 Jul;17(7):676-82 PMID: 10404161
  54. Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase.
    Eur J Biochem. 1999 Oct;265(2):754-62 PMID: 10504407
  55. Regulation of nuclear localization: a key to a door.
    Annu Rev Cell Dev Biol. 1999;15:291-339 PMID: 10611964
  56. Inhibition of TATA-binding protein function by SAGA subunits Spt3 and Spt8 at Gcn4-activated promoters.
    Mol Cell Biol. 2000 Jan;20(2):634-47 PMID: 10611242
  57. Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins.
    Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14866-70 PMID: 10611304
  58. The TOR signaling cascade regulates gene expression in response to nutrients.
    Genes Dev. 1999 Dec 15;13(24):3271-9 PMID: 10617575
  59. A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha.
    Genetics. 2000 Feb;154(2):787-801 PMID: 10655230
  60. Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCF(CDC4) ubiquitin-ligase complex.
    Mol Biol Cell. 2000 Mar;11(3):915-27 PMID: 10712509
  61. Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.
    Mol Cell Biol. 2000 Apr;20(7):2505-16 PMID: 10713174
  62. Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase.
    Mol Cell Biol. 2000 Apr;20(8):2706-17 PMID: 10733573
  63. Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutants.
    FEBS Lett. 2000 Mar 24;470(2):156-60 PMID: 10734226
  64. Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation.
    EMBO J. 2000 Apr 17;19(8):1887-99 PMID: 10775272
  65. The yeast A kinases differentially regulate iron uptake and respiratory function.
    Proc Natl Acad Sci U S A. 2000 May 23;97(11):5984-8 PMID: 10811893
  66. A complex containing two transcription factors regulates peroxisome proliferation and the coordinate induction of beta-oxidation enzymes in Saccharomyces cerevisiae.
    Mol Cell Biol. 1997 Jan;17(1):69-80 PMID: 8972187
  67. Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2.
    Mol Cell Biol. 1997 Aug;17(8):4474-89 PMID: 9234705
  68. Exploring the metabolic and genetic control of gene expression on a genomic scale.
    Science. 1997 Oct 24;278(5338):680-6 PMID: 9381177
  69. MIPS: a database for protein sequences and complete genomes.
    Nucleic Acids Res. 1998 Jan 1;26(1):33-7 PMID: 9399795
  70. Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin.
    FEBS Lett. 1998 Jan 9;421(2):125-30 PMID: 9468292
  71. The Gcn4p activation domain interacts specifically in vitro with RNA polymerase II holoenzyme, TFIID, and the Adap-Gcn5p coactivator complex.
    Mol Cell Biol. 1998 Mar;18(3):1711-24 PMID: 9488488
  72. The transcriptional regulator Hap1p (Cyp1p) is essential for anaerobic or heme-deficient growth of Saccharomyces cerevisiae: Genetic and molecular characterization of an extragenic suppressor that encodes a WD repeat protein.
    Genetics. 1998 Feb;148(2):559-69 PMID: 9504906
  73. Monitoring the Gcn4 protein-mediated response in the yeast Saccharomyces cerevisiae.
    J Biol Chem. 1998 May 22;273(21):12696-702 PMID: 9582292
  74. Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae.
    EMBO J. 1998 Jun 15;17(12):3326-41 PMID: 9628870
  75. Expression monitoring by hybridization to high-density oligonucleotide arrays.
    Nat Biotechnol. 1996 Dec;14(13):1675-80 PMID: 9634850
  76. Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae.
    FEBS Lett. 1998 Jun 23;430(1-2):116-25 PMID: 9678606
  77. Synthesis of glutamine, glycine and 10-formyl tetrahydrofolate is coregulated with purine biosynthesis in Saccharomyces cerevisiae.
    Mol Gen Genet. 1998 Aug;259(3):246-55 PMID: 9749667
  78. Transcriptional activation by Gcn4p involves independent interactions with the SWI/SNF complex and the SRB/mediator.
    Mol Cell. 1999 Oct;4(4):657-64 PMID: 10549298
  79. Molecular mechanism of autophagy in yeast, Saccharomyces cerevisiae.
    Philos Trans R Soc Lond B Biol Sci. 1999 Sep 29;354(1389):1577-80; discussion 1580-1 PMID: 10582243
  80. Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast.
    Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7957-62 PMID: 10884426
  81. GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast.
    J Biol Chem. 2000 Jul 7;275(27):20243-6 PMID: 10801780
  82. Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain.
    Mol Cell. 2000 Aug;6(2):269-79 PMID: 10983975
  83. Global expression profiling of yeast treated with an inhibitor of amino acid biosynthesis, sulfometuron methyl.
    Physiol Genomics. 2000 Aug 9;3(2):83-92 PMID: 11015603
  84. Regulatory networks revealed by transcriptional profiling of damaged Saccharomyces cerevisiae cells: Rpn4 links base excision repair with proteasomes.
    Mol Cell Biol. 2000 Nov;20(21):8157-67 PMID: 11027285
  85. Identification of the copper regulon in Saccharomyces cerevisiae by DNA microarrays.
    J Biol Chem. 2000 Oct 13;275(41):32310-6 PMID: 10922376
  86. Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells.
    EMBO J. 2000 Dec 1;19(23):6622-33 PMID: 11101534
  87. Autophagy as a regulated pathway of cellular degradation.
    Science. 2000 Dec 1;290(5497):1717-21 PMID: 11099404
  88. Genomic expression programs in the response of yeast cells to environmental changes.
    Mol Biol Cell. 2000 Dec;11(12):4241-57 PMID: 11102521
  89. The Sko1p repressor and Gcn4p activator antagonistically modulate stress-regulated transcription in Saccharomyces cerevisiae.
    Mol Cell Biol. 2001 Jan;21(1):16-25 PMID: 11113177
  90. Genome-wide location and function of DNA binding proteins.
    Science. 2000 Dec 22;290(5500):2306-9 PMID: 11125145
  91. Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF.
    Nature. 2001 Jan 25;409(6819):533-8 PMID: 11206552
Article Info
Journal
Eukaryotic cell
Abbr.
Eukaryot Cell
ISSN
1535-9778
DOI
10.1128/EC.01.1.22-32.2002
Email
[email protected]
Published
2002-02-00
Pages
22-32
Language
English
Region
United States
NLM ID
101130731
PMCID
PMC118051
Subset
IM
External Links
PubMed source DOI: 10.1128/EC.01.1.22-32.2002 PMC Full Text View journal details
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