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PMID: 1248865 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Effect of fatty acids on Staphylococcus aureus delta-toxin hemolytic activity.

Infection and immunity ·Vol. 13 ·No. 1 ·1976-01-00 ·Pages 114-9

Kapral FA

Abstract

The lysis of human erythrocytes by Staphylococcus aureus delta-toxin proceeded without a lag and was directly proportional to toxin concentration and temperature of incubation. Lysis was complete within 8 min. Addition of saturated, straight-chain fatty acids of 13 to 19 carbons increased the activity of delta-toxin, whereas those with 21 to 23 carbons were inhibitory. Palmitic acid was the fatty acid most active in augmenting delta-toxin, but its effect could be abolished by the simultaneous addition of either tricosanoic acid or egg lecithin.

MeSH Terms
Fatty Acids/pharmacology Hemolysis/drug effects Humans Palmitic Acids/pharmacology Phosphatidylcholines/pharmacology Staphylococcus aureus Toxins, Biological
Chemicals
Fatty Acids Palmitic Acids Phosphatidylcholines Toxins, Biological
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kapral F A
References (12)
12 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.13.1.114-119.1976
Published
1976-01-00
Pages
114-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC420584
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.13.1.114-119.1976 PMC Full Text View journal details
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