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PMID: 1248867 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Inhibition of water absorption in the intestine by Staphylococcus aureus delta-toxin.

Infection and immunity ·Vol. 13 ·No. 1 ·1976-01-00 ·Pages 140-5

Kapral FA, O'Brien AD, Ruff PD, Drugan WJ

Abstract

Water absorption in intestinal segments was monitored by measuring the concentration of polyethylene glycol, a nonabsorbable reference marker, in a balanced salt solution continuously perfused through the lumen. Staphylococcus aureus delta-toxin inhibited water absorption in rabbit jejunum and ileum perfused in vivo and in guinea pig ileum perfused in vitro. Cholera toxin also interfered with water absorption in guinea pig ileum maintained in vitro, but S. aureus enterotoxin B had no demonstrable effect on this tissue.

MeSH Terms
Animals Biological Transport Dose-Response Relationship, Drug Guinea Pigs Ileum/metabolism Jejunum/metabolism Perfusion Rabbits Staphylococcus aureus Toxins, Biological/pharmacology Water-Electrolyte Balance
Chemicals
Toxins, Biological
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kapral F A
O'Brien A D
Ruff P D
Drugan W J
References (8)
8 references, click to expand
  1. Time of onset of action of cholera toxin in dog and rabbit.
    Gastroenterology. 1969 Jul;57(1):5-8 PMID: 5788651
  2. Cyclic nucleotides and their role in gastrointestinal secretion.
    Gastroenterology. 1974 Nov;67(5):1023-64 PMID: 4154262
  3. Effect of staphylococcal enterotoxins A, B, and C, on ion transport and permeability across the flounder intestine.
    Proc Soc Exp Biol Med. 1974 Oct;147(1):250-4 PMID: 4438330
  4. Effects of staphylococcal enterotoxin B on intestinal transport in the rat.
    Am J Physiol. 1971 Jun;220(6):1793-7 PMID: 5087828
  5. Product of Staphylococcus aureus responsible for the scalded-skin syndrome.
    Infect Immun. 1971 Nov;4(5):541-5 PMID: 5154894
  6. Absorption of sugars from isolated surviving intestine.
    Arch Biochem Biophys. 1953 Mar;43(1):194-207 PMID: 13031675
  7. Increased cyclic adenosine 3',5'-monophosphate content in guinea pig ileum after exposure to Staphylococcus aureus delta-toxin.
    Infect Immun. 1976 Jan;13(1):152-62 PMID: 175015
  8. Inhibition of Staphylococcus aureus delta hemolysin by phospholipids.
    Proc Soc Exp Biol Med. 1972 Nov;141(2):519-21 PMID: 4673911
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.13.1.140-145.1976
Published
1976-01-00
Pages
140-5
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC420588
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.13.1.140-145.1976 PMC Full Text View journal details
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