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PMID: 12514132 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Retinoids regulate the anterior expression boundaries of 5' Hoxb genes in posterior hindbrain.

The EMBO journal ·Vol. 22 ·No. 2 ·2003-01-15 ·Pages 262-9

Oosterveen T, Niederreither K, Dollé P, Chambon P, Meijlink F, Deschamps J

Abstract

We describe the regulatory interactions that cause anterior extension of the mouse 5' Hoxb expression domains from spinal cord levels to their definitive boundaries in the posterior hindbrain between embryonic day E10 and E11.5. This anterior expansion is retinoid dependent since it does not occur in mouse embryos deficient for the retinoic acid-synthesizing enzyme retinaldehyde dehydrogenase 2. A retinoic acid response element (RARE) was identified downstream of Hoxb5 and shown to be essential for expression of Hoxb5 and Hoxb8 reporter transgenes in the anterior neural tube. The spatio-temporal activity of this element overlaps with rostral extension of the expression domain of endogenous Hoxb5, Hoxb6 and Hoxb8 into the posterior hindbrain. The RARE and surrounding sequences are found at homologous positions in the human, mouse and zebrafish genome, which supports an evolutionarily conserved regulatory function.

MeSH Terms
5' Flanking Region/genetics Aldehyde Oxidoreductases/genetics Animals Central Nervous System/embryology,physiology Embryo, Mammalian Embryonic Structures/physiology Evolution, Molecular Gene Expression Regulation, Developmental Genes, Homeobox Genes, Reporter Homeodomain Proteins/genetics Humans In Situ Hybridization Mice Morphogenesis Multigene Family Response Elements Retinal Dehydrogenase Retinoids/metabolism Rhombencephalon/embryology,physiology Signal Transduction/physiology Transgenes Zebrafish Proteins
Chemicals
HOXB5 protein, human HOXB8 protein, human Homeodomain Proteins Hoxb5 protein, mouse Hoxb8 protein, mouse Retinoids Zebrafish Proteins hoxb5a protein, zebrafish hoxb5b protein, zebrafish Aldehyde Oxidoreductases Retinal Dehydrogenase
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Oosterveen Tony
Hubrecht Laboratory, The Netherlands Institute of Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.
Niederreither Karen
Dollé Pascal
Chambon Pierre
Meijlink Frits
Deschamps Jacqueline
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
DOI
10.1093/emboj/cdg029
Published
2003-01-15
Pages
262-9
Language
English
Region
England
NLM ID
8208664
PMCID
PMC140104
Subset
IM
External Links
PubMed source DOI: 10.1093/emboj/cdg029 PMC Full Text View journal details
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