Abstract
In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data analysis and retrieval resources for the data in GenBank and other biological data made available through NCBI's Web site. NCBI resources include Entrez, PubMed, PubMed Central (PMC), LocusLink, the NCBITaxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR (e-PCR), Open Reading Frame (ORF) Finder, References Sequence (RefSeq), UniGene, HomoloGene, ProtEST, Database of Single Nucleotide Polymorphisms (dbSNP), Human/Mouse Homology Map, Cancer Chromosome Aberration Project (CCAP), Entrez Genomes and related tools, the Map Viewer, Model Maker (MM), Evidence Viewer (EV), Clusters of Orthologous Groups (COGs) database, Retroviral Genotyping Tools, SAGEmap, Gene Expression Omnibus (GEO), Online Mendelian Inheritance in Man (OMIM), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), and the Conserved Domain Architecture Retrieval Tool (CDART). Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of the resources can be accessed through the NCBI home page at: http://www.ncbi.nlm.nih.gov.
MeSH Terms
Animals
Biotechnology
Chromosome Mapping
Databases, Genetic
Gene Expression Profiling
Genes
Genome
Humans
Information Storage and Retrieval
Mice
Models, Molecular
Phenotype
Protein Structure, Tertiary
Sequence Alignment/methods
Sequence Homology
United States
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Wheeler David L
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
[email protected]
Church Deanna M
Federhen Scott
Lash Alex E
Madden Thomas L
Pontius Joan U
Schuler Gregory D
Schriml Lynn M
Sequeira Edwin
Tatusova Tatiana A
Wagner Lukas
References (24)
24 references, click to expand
-
RefSeq and LocusLink: NCBI gene-centered resources.
Nucleic Acids Res. 2001 Jan 1;29(1):137-40
PMID: 11125071
-
Complete genomes in WWW Entrez: data representation and analysis.
Bioinformatics. 1999 Jul-Aug;15(7-8):536-43
PMID: 10487861
-
Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements.
Nucleic Acids Res. 2001 Jul 15;29(14):2994-3005
PMID: 11452024
-
GenBank.
Nucleic Acids Res. 2002 Jan 1;30(1):17-20
PMID: 11752243
-
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository.
Nucleic Acids Res. 2002 Jan 1;30(1):207-10
PMID: 11752295
-
Recent improvements to the SMART domain-based sequence annotation resource.
Nucleic Acids Res. 2002 Jan 1;30(1):242-4
PMID: 11752305
-
The Pfam protein families database.
Nucleic Acids Res. 2002 Jan 1;30(1):276-80
PMID: 11752314
-
PatternHunter: faster and more sensitive homology search.
Bioinformatics. 2002 Mar;18(3):440-5
PMID: 11934743
-
MMDB: Entrez's 3D-structure database.
Nucleic Acids Res. 2003 Jan 1;31(1):474-7
PMID: 12520055
-
Basic local alignment search tool.
J Mol Biol. 1990 Oct 5;215(3):403-10
PMID: 2231712
-
Entrez: molecular biology database and retrieval system.
Methods Enzymol. 1996;266:141-62
PMID: 8743683
-
A breakpoint map of recurrent chromosomal rearrangements in human neoplasia.
Nat Genet. 1997 Apr;15 Spec No:417-74
PMID: 9140409
-
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
Nucleic Acids Res. 1997 Sep 1;25(17):3389-402
PMID: 9254694
-
Pieces of the puzzle: expressed sequence tags and the catalog of human genes.
J Mol Med (Berl). 1997 Oct;75(10):694-8
PMID: 9382993
-
Data management and analysis for gene expression arrays.
Nat Genet. 1998 Sep;20(1):19-23
PMID: 9731524
-
The COG database: a tool for genome-scale analysis of protein functions and evolution.
Nucleic Acids Res. 2000 Jan 1;28(1):33-6
PMID: 10592175
-
The protein information resource (PIR).
Nucleic Acids Res. 2000 Jan 1;28(1):41-4
PMID: 10592177
-
The Protein Data Bank.
Nucleic Acids Res. 2000 Jan 1;28(1):235-42
PMID: 10592235
-
Cn3D: sequence and structure views for Entrez.
Trends Biochem Sci. 2000 Jun;25(6):300-2
PMID: 10838572
-
A greedy algorithm for aligning DNA sequences.
J Comput Biol. 2000 Feb-Apr;7(1-2):203-14
PMID: 10890397
-
SAGEmap: a public gene expression resource.
Genome Res. 2000 Jul;10(7):1051-60
PMID: 10899154
-
CluSTr: a database of clusters of SWISS-PROT+TrEMBL proteins.
Nucleic Acids Res. 2001 Jan 1;29(1):33-6
PMID: 11125042
-
BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences.
FEMS Microbiol Lett. 1999 May 15;174(2):247-50
PMID: 10339815
-
dbSNP: the NCBI database of genetic variation.
Nucleic Acids Res. 2001 Jan 1;29(1):308-11
PMID: 11125122