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PMID: 125222 Published · ppublish English Journal Article

Linkage group HL-A-MLC-BF (properdin factor B). The site of the Bf locus at the immunogenetic linkage group on chromosome 6.

Humangenetik ·Vol. 27 ·No. 3 ·1975-00-00 ·Pages 173-83

Rittner C, Grosse-Wilde H, Netzel B, Scholz S, Lorenz H, Albert ED

Abstract

Genetic linkage between the HL-A and Bf loci could be confirmed in 43 families with 168 offspring. In 4 families, 5 recombinants out of 82 informative meiotic divisions were observed (r = 6.1%). The localisation of the Bf marker system was studied in 3 families with crossovers between HL-A and MLC. From these data the following map order of human chromosome 6 can be proposed: HL-A (1st locus) -- HL-A (2nd locus)--MLC-Bf---PGM(3). The fact that important components of the classical and alternate pathway of complement activation are governed by genes closely linked with HL-A and MLC loci leads to the proposition to include the Bf system into the Major Histocompatibility Complex in man.

MeSH Terms
Chromosome Mapping Chromosomes, Human, 6-12 and X Complement System Proteins Crossing Over, Genetic Electrophoresis, Starch Gel Female Gene Frequency Genetic Linkage Germany, West HLA Antigens Histocompatibility Histocompatibility Antigens Humans Immunogenetics Lymphocyte Culture Test, Mixed Male Phenotype Phosphoglucomutase Polymorphism, Genetic Properdin Recombination, Genetic
Chemicals
HLA Antigens Histocompatibility Antigens Properdin Complement System Proteins Phosphoglucomutase
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Rittner C
Grosse-Wilde H
Netzel B
Scholz S
Lorenz H
Albert E D
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29 references, click to expand
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Article Info
Journal
Humangenetik
Abbr.
Humangenetik
ISSN
0018-7348
DOI
10.1007/BF00278344
Published
1975-00-00
Pages
173-83
Language
English
Region
Germany
NLM ID
7607154
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00278344
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