Effect of methylmercury on humoral immune responses in mice under conditions simulated to practical situations.

Bulletin of environmental contamination and toxicology ·Vol. 15 ·No. 2 ·1976-02-00 ·Pages 175-80

Ohi G, Fukuda M, Seto H, Yagyu H

Abstract

A suppression and delay in reaching the peak of primary humoral response in mice was noted when relatively large dosage of methylmercury was administered in a short time period, suggesting the interference with the initial multiplications of antibody producing cells. On the other hand, subchronic administration of low levels of methylmercury in diet (0.5 and 5ppm) caused no definite suppression on either primary or secondary responses, though they tended to be depressed.

MeSH Terms

Age Factors Animals Diet Erythrocytes/immunology Immunity/drug effects Male Methylmercury Compounds/pharmacology Mice Mice, Inbred ICR Organ Size/drug effects Sheep/immunology Spleen/drug effects Thymus Gland/drug effects Time Factors

Chemicals

Methylmercury Compounds

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Ohi G

Fukuda M

Seto H

Yagyu H

References (10)

10 references, click to expand

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Article Info

Journal

Bulletin of environmental contamination and toxicology

Abbr.

Bull Environ Contam Toxicol

ISSN

0007-4861

DOI

10.1007/BF01685157

Published

1976-02-00

Pages

175-80

Language

English

Region

United States

NLM ID

0046021

Subset

External Links

PubMed source DOI: 10.1007/BF01685157 View journal details

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Effect of methylmercury on humoral immune responses in mice under conditions simulated to practical situations.

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