Home LiteratureArticle Details
PMID: 12529315 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

The comprehensive mouse radiation hybrid map densely cross-referenced to the recombination map: a tool to support the sequence assemblies.

Genome research ·Vol. 13 ·No. 1 ·2003-01-00 ·Pages 122-33

Rowe LB, Barter ME, Kelmenson JA, Eppig JT

Abstract

We have developed a unique comprehensive mouse radiation hybrid (RH) map of nearly 23,000 markers integrating data from three international genome centers and over 400 independent laboratories. We have cross-referenced this map to the 0.5-cM resolution recombination-based Jackson Laboratory (TJL) backcross panel map, building a complete set of RH framework chromosome maps based on a high density of known-ordered anchor markers. We have systematically typed markers to improve coverage and resolve discrepancies, and have reanalyzed data sets as needed. The cross-linking of the RH and recombination maps has resulted in a highly accurate genome-wide map with consistent marker order. We have compared these linked framework maps to the Ensemble mouse genome sequence assembly, and show that they are a useful medium resolution tool for both validating sequence assembly and elucidating chromosome biology.

MeSH Terms
Animals Animals, Wild Chromosomes/genetics Contig Mapping Cricetinae Crosses, Genetic DNA/genetics Gene Order/genetics Genetic Markers/genetics Mice Mice, Inbred C57BL Mice, Inbred Strains Radiation Hybrid Mapping/methods Recombination, Genetic/genetics X Chromosome/genetics
Chemicals
Genetic Markers DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rowe Lucy B
The Jackson Laboratory, Bar Harbor, Maine 04609, USA. [email protected]
Barter Mary E
Kelmenson Jennifer A
Eppig Janan T
References (34)
34 references, click to expand
  1. A radiation hybrid transcript map of the mouse genome.
    Nat Genet. 2001 Oct;29(2):194-200 PMID: 11586301
  2. A comparison of the Celera and Ensembl predicted gene sets reveals little overlap in novel genes.
    Cell. 2001 Aug 24;106(4):413-5 PMID: 11534548
  3. Genetic, physical, and phenotypic characterization of the Del(13)Svea36H mouse.
    Mamm Genome. 2001 Sep;12(9):687-94 PMID: 11641716
  4. Crossover interference in the mouse.
    Genetics. 2002 Mar;160(3):1123-31 PMID: 11901128
  5. The functional significance of absence: the chromosomal segment harboring Tp53 is absent from the T55 rat radiation hybrid mapping panel.
    Genomics. 2002 Jun;79(6):844-8 PMID: 12036299
  6. Comparative analysis of human genome assemblies reveals genome-level differences.
    Genomics. 2002 Aug;80(2):138-9 PMID: 12160725
  7. Molecular characterization of the Pb recombination hotspot in the mouse major histocompatibility complex class II region.
    Genomics. 2002 Aug;80(2):229-35 PMID: 12160737
  8. A physical map of the mouse genome.
    Nature. 2002 Aug 15;418(6899):743-50 PMID: 12181558
  9. Evolution of mouse chromosome 17 and the origin of inversions associated with t haplotypes.
    Proc Natl Acad Sci U S A. 1989 May;86(9):3261-5 PMID: 2717616
  10. A genetic linkage map of the mouse: current applications and future prospects.
    Science. 1993 Oct 1;262(5130):57-66 PMID: 8211130
  11. Towards high resolution maps of the mouse and human genomes--a facility for ordering markers to 0.1 cM resolution. European Backcross Collaborative Group.
    Hum Mol Genet. 1994 Apr;3(4):621-7 PMID: 8069308
  12. Maps from two interspecific backcross DNA panels available as a community genetic mapping resource.
    Mamm Genome. 1994 May;5(5):253-74 PMID: 8075499
  13. Chiasma frequency, distribution and interference maps of mouse autosomes.
    Chromosoma. 1995 Dec;104(4):308-14 PMID: 8565707
  14. A comprehensive genetic map of the mouse genome.
    Nature. 1996 Mar 14;380(6570):149-52 PMID: 8600386
  15. A gene map of the human genome.
    Science. 1996 Oct 25;274(5287):540-6 PMID: 8849440
  16. A radiation hybrid map of the human genome.
    Hum Mol Genet. 1996 Mar;5(3):339-46 PMID: 8852657
  17. An STS-based radiation hybrid map of the human genome.
    Genome Res. 1997 May;7(5):422-33 PMID: 9149939
  18. Meiotic recombination hotspots: shaping the genome and insights into hypervariable minisatellite DNA change.
    Curr Top Dev Biol. 1998;37:37-75 PMID: 9352183
  19. A first-generation whole genome-radiation hybrid map spanning the mouse genome.
    Genome Res. 1997 Dec;7(12):1153-61 PMID: 9414320
  20. A high-resolution microsatellite map of the mouse genome.
    Genome Res. 1998 May;8(5):531-42 PMID: 9582196
  21. Refined radiation hybrid map of mouse chromosome 17.
    Mamm Genome. 1998 Oct;9(10):807-11 PMID: 9745034
  22. Integrated YAC/STS physical and genetic map of 22.5 Mb of human Xq24-q26 at 56-kb inter-STS resolution.
    Genomics. 1998 Sep 15;52(3):247-66 PMID: 9790744
  23. Overview of QTL mapping software and introduction to map manager QT.
    Mamm Genome. 1999 Apr;10(4):327-34 PMID: 10087288
  24. A radiation hybrid map of mouse chromosome 13.
    Genomics. 1999 May 1;57(3):365-70 PMID: 10329002
  25. A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat.
    Genome Res. 1999 Jun;9(6):AP1-8, insert PMID: 10400928
  26. Radiation hybrid map of the mouse genome.
    Nat Genet. 1999 Aug;22(4):384-7 PMID: 10431245
  27. An integrated linkage-radiation hybrid map of the canine genome.
    Mamm Genome. 2000 Feb;11(2):120-30 PMID: 10656926
  28. Comparative gene mapping workshop: progress in agriculturally important animals.
    Mamm Genome. 2000 Feb;11(2):140-4 PMID: 10656929
  29. The mouse Psma1 gene coding for the alpha-type C2 proteasome subunit: structural and functional analysis, mapping, and colocalization with Pde3b on mouse chromosome 7.
    Genomics. 2000 Jun 15;66(3):313-23 PMID: 10873386
  30. Cross-referencing radiation hybrid data to the recombination map: lessons from mouse chromosome 18.
    Genomics. 2000 Oct 1;69(1):27-36 PMID: 11013072
  31. The sequence of the human genome.
    Science. 2001 Feb 16;291(5507):1304-51 PMID: 11181995
  32. Initial sequencing and analysis of the human genome.
    Nature. 2001 Feb 15;409(6822):860-921 PMID: 11237011
  33. Integration of the feline radiation hybrid and linkage maps.
    Mamm Genome. 2001 Jun;12(6):436-41 PMID: 11353390
  34. A radiation hybrid map of mouse genes.
    Nat Genet. 2001 Oct;29(2):201-5 PMID: 11586302
Article Info
Journal
Genome research
Abbr.
Genome Res
ISSN
1088-9051
DOI
10.1101/gr.858103
Email
[email protected]
Published
2003-01-00
Pages
122-33
Language
English
Region
United States
NLM ID
9518021
PMCID
PMC430952
Subset
IM
Grants
NCI NIH HHS · CA34194 · United States
External Links
PubMed source DOI: 10.1101/gr.858103 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2