Home LiteratureArticle Details
PMID: 12531877 Published · ppublish English Comment Journal Article Research Support, Non-U.S. Gov't

Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood.

The Journal of clinical investigation ·Vol. 111 ·No. 2 ·2003-01-00 ·Pages 217-23

Trudeau JD, Kelly-Smith C, Verchere CB, Elliott JF, Dutz JP, Finegood DT, Santamaria P, Tan R

Abstract

Autoimmune (type 1) diabetes mellitus results from the destruction of insulin-producing pancreatic beta cells by T lymphocytes. Prediction of cell-mediated autoimmune diseases by direct detection of autoreactive T cells in peripheral blood has proved elusive, in part because of their low frequency and reduced avidity for peptide MHC ligands. This article was published online in advance of the print edition. The date of publication is available from the JCI website, http://www.jci.org.

MeSH Terms
Animals CD8-Positive T-Lymphocytes/immunology Diabetes Mellitus, Type 1/diagnosis,immunology Epitopes, T-Lymphocyte Female Histocompatibility Antigens Class I/chemistry,metabolism Islets of Langerhans/immunology Lymphocyte Count Mice Mice, Inbred NOD
Chemicals
Epitopes, T-Lymphocyte Histocompatibility Antigens Class I
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Trudeau Jacqueline D
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Kelly-Smith Carolyn
Verchere C Bruce
Elliott John F
Dutz Jan P
Finegood Diane T
Santamaria Pere
Tan Rusung
References (32)
32 references, click to expand
  1. Detection of glutamic acid decarboxylase-activated T cells with I-Ag7 tetramers.
    Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14596-601 PMID: 11106373
  2. Autoreactive CD8 T cells in organ-specific autoimmunity: emerging targets for therapeutic intervention.
    Immunity. 2002 Jul;17(1):1-6 PMID: 12150886
  3. Identification of type II collagen peptide 261-273-specific T cell clones in a patient with relapsing polychondritis.
    Arthritis Rheum. 2002 Jan;46(1):238-44 PMID: 11817597
  4. Progression of autoimmune diabetes driven by avidity maturation of a T-cell population.
    Nature. 2000 Aug 17;406(6797):739-42 PMID: 10963600
  5. Insulin-dependent diabetes mellitus.
    Cell. 1996 May 3;85(3):291-7 PMID: 8616883
  6. Lack of autoimmune serological reactions in rodent models of insulin dependent diabetes mellitus.
    J Autoimmun. 1996 Dec;9(6):705-11 PMID: 9115572
  7. Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes.
    Diabetes. 1994 Mar;43(3):500-4 PMID: 8314024
  8. International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: identification of insulin but not glutamic acid decarboxylase or IA-2 as specific autoantigens of humoral autoimmunity in nonobese diabetic mice.
    Diabetes. 2001 Nov;50(11):2451-8 PMID: 11679421
  9. Expansion of the antigenic repertoire of a single T cell receptor upon T cell activation.
    J Immunol. 2001 Jul 15;167(2):655-66 PMID: 11441068
  10. Modern concepts for the prediction of type 1 diabetes.
    Exp Clin Endocrinol Diabetes. 2001;109 Suppl 2:S304-16 PMID: 11460579
  11. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion.
    Immunity. 2000 Dec;13(6):829-40 PMID: 11163198
  12. The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.
    Immunity. 1997 Dec;7(6):727-38 PMID: 9430219
  13. Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant.
    Diabetes. 1994 Mar;43(3):505-9 PMID: 8314025
  14. Accessing complexity: the dynamics of virus-specific T cell responses.
    Annu Rev Immunol. 2000;18:561-92 PMID: 10837069
  15. Autoimmune type 1 diabetes: resolved and unresolved issues.
    J Clin Invest. 2001 Nov;108(9):1247-52 PMID: 11696564
  16. Low avidity recognition of self-antigen by T cells permits escape from central tolerance.
    Immunity. 1995 Oct;3(4):407-15 PMID: 7584132
  17. T cell affinity maturation by selective expansion during infection.
    J Exp Med. 1999 Feb 15;189(4):701-10 PMID: 9989985
  18. Pathogenesis, prediction and trials for the prevention of insulin-dependent (type 1) diabetes mellitus.
    Adv Drug Deliv Rev. 1999 Feb 1;35(2-3):143-156 PMID: 10837695
  19. Use of soluble peptide-DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis.
    Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):291-6 PMID: 10618411
  20. The NOD mouse model of type 1 diabetes: as good as it gets?
    Nat Med. 1999 Jun;5(6):601-4 PMID: 10371488
  21. A kinetic basis for T cell receptor repertoire selection during an immune response.
    Immunity. 1999 Apr;10(4):485-92 PMID: 10229191
  22. High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo.
    J Exp Med. 1998 Sep 21;188(6):1203-8 PMID: 9743539
  23. Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes.
    J Exp Med. 1999 Jan 18;189(2):331-9 PMID: 9892615
  24. Phenotypic analysis of antigen-specific T lymphocytes.
    Science. 1996 Oct 4;274(5284):94-6 PMID: 8810254
  25. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.
    Nat Med. 1999 Sep;5(9):1026-31 PMID: 10470079
  26. Transient insulin autoantibody expression independent of development of diabetes: comparison of NOD and NOR strains.
    J Autoimmun. 2001 Aug;17(1):1-6 PMID: 11488632
  27. Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice.
    J Exp Med. 1997 Nov 17;186(10):1663-76 PMID: 9362527
  28. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes.
    Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1701-6 PMID: 10677521
  29. Prevalent CD8(+) T cell response against one peptide/MHC complex in autoimmune diabetes.
    Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9311-6 PMID: 10430939
  30. Identification and quantification of a naturally presented peptide as recognized by cytotoxic T lymphocytes specific for an immunogenic tumor variant.
    Int Immunol. 1992 Oct;4(10):1085-90 PMID: 1283332
  31. T cell responses to bacterial infection.
    Curr Opin Immunol. 1999 Aug;11(4):400-5 PMID: 10448135
  32. Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers.
    Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11433-8 PMID: 11005833
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI16409
Published
2003-01-00
Pages
217-23
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC151866
Subset
IM
Corrections
CommentOn
PMID: 12531872
CommentIn
PMID: 26994137
External Links
PubMed source DOI: 10.1172/JCI16409 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2