Effect of intrahepatically implanted islets of Langerhans on hepatic function in the rat.

Mayo Clinic proceedings ·Vol. 50 ·No. 7 ·1975-07-00 ·Pages 416-9

Amamoo DG, Woods JE, Holley KE

Abstract

Diabetes mellitus is satisfactorily controlled in the rat by hepatic implantation of isolated, isologous pancreatic islets. The transplanted islets appear to be viable for at least 6 months after implantation, and hepatic function studies (serum bilirubin, alkaline phosphatase, glutamic-oxalacetic transaminase, prothrombin time) and microscopic examination indicate that they do not interfere with hepatic function.

MeSH Terms

Alkaline Phosphatase/blood Animals Aspartate Aminotransferases/blood Blood Glucose/analysis Diabetes Mellitus/chemically induced,pathology,surgery Hepatectomy Islets of Langerhans Transplantation Liver/pathology,physiology,surgery Liver Function Tests Male Rats Rats, Inbred Lew Streptozocin Time Factors Transplantation, Homologous

Chemicals

Blood Glucose Streptozocin Aspartate Aminotransferases Alkaline Phosphatase

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Amamoo D G

Woods J E

Holley K E

Article Info

Journal

Mayo Clinic proceedings

Abbr.

Mayo Clin Proc

ISSN

0025-6196

Published

1975-07-00

Pages

416-9

Language

English

Region

England

NLM ID

0405543

Subset

External Links

PubMed source View journal details

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Effect of intrahepatically implanted islets of Langerhans on hepatic function in the rat.

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