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PMID: 12538854 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Suppression of cortical representation through backward conditioning.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 100 ·No. 3 ·2003-02-04 ·Pages 1405-8

Bao S, Chan VT, Zhang LI, Merzenich MM

Abstract

Temporal stimulus reinforcement sequences have been shown to determine the directions of synaptic plasticity and behavioral learning. Here, we examined whether they also control the direction of cortical reorganization. Pairing ventral tegmental area stimulation with a sound in a backward conditioning paradigm specifically reduced representations of the paired sound in the primary auditory cortex (AI). This temporal sequence-dependent bidirectional cortical plasticity modulated by dopamine release hypothetically serves to prevent the over-representation of frequently occurring stimuli resulting from their random pairing with unrelated rewards.

MeSH Terms
Adaptation, Physiological/physiology Animals Auditory Cortex/cytology,physiology Conditioning, Psychological/physiology Dopamine/metabolism Electrophysiology Female Neurons/metabolism Rats Synapses Time Factors
Chemicals
Dopamine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bao Shaowen
Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA.
Chan Vincent T
Zhang Li I
Merzenich Michael M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0337527100
Published
2003-02-04
Epub
2003-00-21
Pages
1405-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC298785
Subset
IM
Grants
NINDS NIH HHS · P01 NS034835 · United States
NINDS NIH HHS · R01 NS010414 · United States
NINDS NIH HHS · NS-34835 · United States
NINDS NIH HHS · NS-10414 · United States
NINDS NIH HHS · F32 NS010414 · United States
External Links
PubMed source DOI: 10.1073/pnas.0337527100 PMC Full Text View journal details
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