Leukocyte glutathione peroxidase deficiency in a male patient with chronic granulomatous disease.

The Journal of pediatrics ·Vol. 88 ·No. 4 Pt 1 ·1976-04-00 ·Pages 581-3

Matsuda I, Oka Y, Taniguchi N, Furuyama M, Kodama S, Arashima S, Mitsuyama T

Abstract

A male child with chronic granulomatous disease is described in whom glutathione peroxidase deficiency of leukocytes was identified. Stability and activity of G-6-PD and activity of NADPH oxidase were normal. The leukocytes of the parents showed intermediate activities of glutathione peroxidase, suggesting the possibility of autosomal recessive inheritance.

MeSH Terms

Genes, Recessive Glucosephosphate Dehydrogenase/blood Granulomatous Disease, Chronic/enzymology,genetics Heterozygote Hexosephosphates/metabolism Humans Infant Leukocytes/enzymology Male NADH, NADPH Oxidoreductases/blood Peroxidases/deficiency Phagocyte Bactericidal Dysfunction/enzymology Phosphogluconate Dehydrogenase/blood

Chemicals

Hexosephosphates Phosphogluconate Dehydrogenase Glucosephosphate Dehydrogenase Peroxidases NADH, NADPH Oxidoreductases

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Matsuda I

Oka Y

Taniguchi N

Furuyama M

Kodama S

Arashima S

Mitsuyama T

Article Info

Journal

The Journal of pediatrics

Abbr.

J Pediatr

ISSN

0022-3476

DOI

10.1016/s0022-3476(76)80010-8

Published

1976-04-00

Pages

581-3

Language

English

Region

United States

NLM ID

0375410

Subset

External Links

PubMed source DOI: 10.1016/s0022-3476(76)80010-8 View journal details

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Leukocyte glutathione peroxidase deficiency in a male patient with chronic granulomatous disease.

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