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PMID: 12575899 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer.

Molecular cancer ·Vol. 2 ·2003-01-07 ·Pages 10

Ding XZ, Hennig R, Adrian TE

Abstract

The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer. In this article, we aim to provide a brief summary of (1) our understanding of the roles of these enzymes in pancreatic cancer tumorigenesis and progression; and (2) the potential of using cyclooxygenase and lipoxygenase inhibitors for pancreatic cancer treatment and prevention.

MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use Cyclooxygenase Inhibitors/therapeutic use Humans Lipoxygenase/metabolism Lipoxygenase Inhibitors/therapeutic use Neoplasm Invasiveness/prevention & control Neovascularization, Pathologic/prevention & control Pancreatic Neoplasms/drug therapy,enzymology,prevention & control Prostaglandin-Endoperoxide Synthases/metabolism
Chemicals
Anti-Inflammatory Agents, Non-Steroidal Cyclooxygenase Inhibitors Lipoxygenase Inhibitors Lipoxygenase Prostaglandin-Endoperoxide Synthases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ding Xian-Zhong
Department of Surgery and Robert H, Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry 4-711, Chicago, IL 60611, USA. [email protected]
Hennig Rene
Adrian Thomas E
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Article Info
Journal
Molecular cancer
Abbr.
Mol Cancer
ISSN
1476-4598
DOI
10.1186/1476-4598-2-10
Email
[email protected]
Published
2003-01-07
Epub
2003-00-07
Pages
10
Language
English
Region
England
NLM ID
101147698
PMCID
PMC149414
Subset
IM
Grants
NCI NIH HHS · P50 CA072712 · United States
NCI NIH HHS · P50 CA72712 · United States
External Links
PubMed source DOI: 10.1186/1476-4598-2-10 PMC Full Text View journal details
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