Evolutionary aspects of protein structure and folding.

Current opinion in structural biology ·Vol. 13 ·No. 1 ·2003-02-00 ·Pages 110-4

Trifonov EN, Berezovsky IN

Abstract

The traditional reconstruction of molecular events of the past based on sequence conservation becomes very vague beyond one to two billion years ago. There are certain molecular features, however, such as polymer flexibility and loop closure, that are conserved merely because of their physical nature. This allows one to penetrate the earliest stages of protein evolution.

MeSH Terms

Amino Acid Sequence Conserved Sequence Evolution, Molecular Models, Molecular Molecular Sequence Data Protein Conformation Protein Folding Proteins/chemistry,genetics

Chemicals

Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Trifonov Edward N

Genome Diversity Center, Institute of Evolution, University of Haifa, Haifa 31905, Israel. [email protected]

Berezovsky Igor N

Article Info

Journal

Current opinion in structural biology

Abbr.

Curr Opin Struct Biol

ISSN

0959-440X

DOI

10.1016/s0959-440x(03)00005-8

[email protected]

Published

2003-02-00

Pages

110-4

Language

English

Region

England

NLM ID

9107784

Subset

External Links

PubMed source DOI: 10.1016/s0959-440x(03)00005-8 View journal details

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Evolutionary aspects of protein structure and folding.

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