The evolutionary conservation of the mammalian peroxidase genes.

Myeloperoxidase (MPO), eosinophil peroxidase (EPX) and lactoperoxidase (LPO) are mammalian peroxidase enzymes possessing similar structures and functions. Here, we demonstrate that the genes encoding these molecules form a cluster on mouse chromosome 11. Genomic sequence analysis revealed that the mouse LPO gene has similar genomic organization to the corresponding human gene. Our data strongly suggest the evolutionary conservation of mammalian peroxidase genes.