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PMID: 12597703 Published · ppublish English Clinical Trial Comparative Study Evaluation Study Journal Article Multicenter Study Randomized Controlled Trial

The effect of methylphenidate on three forms of response inhibition in boys with AD/HD.

Journal of abnormal child psychology ·Vol. 31 ·No. 1 ·2003-02-00 ·Pages 105-20

Scheres A, Oosterlaan J, Swanson J, Morein-Zamir S, Meiran N, Schut H, Vlasveld L, Sergeant JA

Abstract

The current study was aimed at (a) investigating the effect of three doses methylphenidate (MPH) and placebo on inhibition of a prepotent response, inhibition of an ongoing response, and interference control in Attention Deficit/Hyperactivity Disorder (AD/HD), and (b) studying dose-response relations for the three forms of response inhibition. To meet these aims, the following tasks were selected: two versions of the Stop Paradigm for inhibition of a prepotent response, a Circle Tracing Task and a recently developed Follow Task for inhibition of an ongoing response, and the Stroop Color-Word Test and an Eriksen Flanker Task for interference control. These tasks were administered to 23 boys with AD/HD during four treatment conditions: 5 mg MPH, 10 mg MPH, 20 mg MPH, and placebo. A pseudorandomized, multiple-blind, placebo-controlled, within-subject design was used. As hypothesized, inhibitory control in children with AD/HD improved under MPH compared to placebo. However, this effect was only significant for inhibition of a prepotent response and inhibition of an ongoing response (as measured by the Follow Task), but not for interference control. The relation between treatment condition and response was linear. However, this linear relation was due to improved inhibitory control under MPH compared to placebo, because no effects of MPH dose were observed for any of the response inhibition measures.

MeSH Terms
Attention/drug effects Attention Deficit Disorder with Hyperactivity/diagnosis,drug therapy,psychology Attention Deficit and Disruptive Behavior Disorders/diagnosis,drug therapy,psychology Central Nervous System Stimulants/administration & dosage,adverse effects Child Child Behavior Disorders/diagnosis,drug therapy,psychology Dose-Response Relationship, Drug Double-Blind Method Humans Inhibition, Psychological Male Methylphenidate/administration & dosage,adverse effects Neuropsychological Tests Reaction Time/drug effects Treatment Outcome
Chemicals
Central Nervous System Stimulants Methylphenidate
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Scheres Anouk
Department of Clinical Neuropsychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. [email protected]
Oosterlaan Jaap
Swanson James
Morein-Zamir Sharon
Meiran Nachson
Schut Harry
Vlasveld Laurens
Sergeant Joseph A
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Article Info
Journal
Journal of abnormal child psychology
Abbr.
J Abnorm Child Psychol
ISSN
0091-0627
DOI
10.1023/a:1021729501230
Email
[email protected]
Published
2003-02-00
Pages
105-20
Language
English
Region
United States
NLM ID
0364547
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1021729501230
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