Immune complex type glomerulonephritis in cirrhosis of the liver.

The American journal of pathology ·Vol. 80 ·No. 2 ·1975-08-00 ·Pages 329-40

Callard P, Feldmann G, Prandi D, Belair MF, Mandet C, Weiss Y, Druet P, Benhamou JP, Bariety J

Abstract

Glomerular lesions were detected in 9 of 10 patients with liver cirrhosis: these lesions consisted of a) thickening of basement-membrane-like material, b) electron-dense deposits in mesangial areas and in capillary walls, c) round areas of rarefaction in the membrane-like material and in some deposits, and d) presence of IgA, with IgG and/or IgM and/or C3, in the deposits. The association of these four abnormalities seems to be characteristic of "cirrhotic glomerulonephritis." The deposits could be the result of precipitation in the glomeruli of either aggregated immunoglobulins or circulating immune complexes.

MeSH Terms

Adult Aged Basement Membrane/immunology Complement C3/analysis Cryoglobulins/analysis Female Fluorescent Antibody Technique Glomerulonephritis/complications,immunology Humans Immune Complex Diseases/complications,immunology Immunoglobulin A/analysis Immunoglobulin G/analysis Immunoglobulin M/analysis Liver Cirrhosis/complications,immunology Male Microscopy, Electron Middle Aged

Chemicals

Complement C3 Cryoglobulins Immunoglobulin A Immunoglobulin G Immunoglobulin M

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Callard P

Feldmann G

Prandi D

Belair M F

Mandet C

Weiss Y

Druet P

Benhamou J P

Bariety J

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31 references, click to expand

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Article Info

Journal

The American journal of pathology

Abbr.

Am J Pathol

ISSN

0002-9440

Published

1975-08-00

Pages

329-40

Language

English

Region

United States

NLM ID

0370502

PMCID

PMC1912920

Subset

External Links

PubMed source PMC Full Text View journal details

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