Home LiteratureArticle Details
PMID: 12610296 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Aging and genome maintenance: lessons from the mouse?

Science (New York, N.Y.) ·Vol. 299 ·No. 5611 ·2003-02-28 ·Pages 1355-9

Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J

Abstract

Recent progress in the science of aging is driven largely by the use of model systems, ranging from yeast and nematodes to mice. These models have revealed conservation in genetic pathways that balance energy production and its damaging by-products with pathways that preserve somatic maintenance. Maintaining genome integrity has emerged as a major factor in longevity and cell viability. Here we discuss the use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans.

MeSH Terms
Aging/genetics Aging, Premature/genetics Animals Apoptosis Cellular Senescence DNA Damage DNA Helicases/genetics,metabolism DNA Repair/genetics Exodeoxyribonucleases Genome Genome, Human Humans Longevity/genetics Mice Mutation Reactive Oxygen Species/metabolism RecQ Helicases Syndrome Telomere/physiology Transcription, Genetic Werner Syndrome Helicase
Chemicals
Reactive Oxygen Species Exodeoxyribonucleases DNA Helicases RecQ Helicases WRN protein, human Werner Syndrome Helicase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hasty Paul
Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX 78245, USA. [email protected]
Campisi Judith
Hoeijmakers Jan
van Steeg Harry
Vijg Jan
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1079161
Email
[email protected]
Published
2003-02-28
Pages
1355-9
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NIA NIH HHS · AG17242 · United States
External Links
PubMed source DOI: 10.1126/science.1079161 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2