Abstract
The ability of the host to recognize pulmonary invasion by pathogenic organisms and establish an appropriate host response to infection requires innate immune defense mechanisms. Early bacterial clearance in the lung is mediated by alveolar macrophages (AM) and polymorphonuclear neutrophils. Additionally alveolar epithelial cells type II (AEC-II) may act as immunoregulatory cells. The toll-like receptors (TLR) are part of this innate immune defense, recognizing conserved patterns on microorganisms. Toll-like receptor 2 (TLR2) is crucial in detecting components of gram-positive bacteria and mycobacteria. Signals initiated by the interaction of TLR2 with bacterial components direct the subsequent inflammatory response. The detection of TLR2 mRNA in human lung tissue prompted us to localize the expression of mRNA and protein at the cellular level using a novel method for tissue fixation. We utilized HOPE-fixed lung specimen sections for targeting mRNA by in situ hybridization and protein by immunohistochemistry using the monoclonal antibody TL2.1. In normal lung areas the expression of TLR2 mRNA and protein was found to be located in cells resembling AEC-II and AM. Expression of mRNA was verified by RT-PCR and DNA sequencing. These results indicate a potential mechanism of increased immunosurveillance at the alveolar level controlling the localized infection.
MeSH Terms
Epithelium/metabolism
Humans
Immunohistochemistry
Immunologic Surveillance/physiology
In Situ Hybridization
Macrophages/cytology,metabolism
Membrane Glycoproteins/genetics,metabolism
Oligonucleotide Probes/chemistry
Pulmonary Alveoli/cytology,metabolism
RNA, Messenger/metabolism
Receptors, Cell Surface/genetics,metabolism
Reverse Transcriptase Polymerase Chain Reaction
Tissue Fixation
Toll-Like Receptor 2
Toll-Like Receptors
Chemicals
Membrane Glycoproteins
Oligonucleotide Probes
RNA, Messenger
Receptors, Cell Surface
TLR2 protein, human
Toll-Like Receptor 2
Toll-Like Receptors
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Droemann Daniel
Medical Clinic, Research Center Borstel, Parkallee 35, Germany.
Goldmann Torsten
Branscheid Detlev
Clark Ryan
Dalhoff Klaus
Zabel Peter
Vollmer Ekkehard
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