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PMID: 1261089 Published · ppublish English Journal Article

Autoimmunity and viral infection in diabetes mellitus.

Clinical and experimental immunology ·Vol. 23 ·No. 1 ·1976-01-00 ·Pages 40-6

Richens ER, Ancil RJ

Abstract

Forty-three newly diagnosed insulin-dependent diabetics and thirty control subjects have been examined for cellular hypersensitivity to different pancreatic preparations, rat liver mitochondria and Coxsackie B4 virus. Evidence for cellular hypersensitivity to the pancreatic preparations was shown in the diabetic group, in whom the hypersensitivity to the pancreatic preparations was found to correlate with hypersensitivity to rat liver mitochondria. Hypersensitivity to Coxsackie B4 virus was not found to differ significantly in the diabetic and control groups. Hypersensitivity to liver mitochondria appeared to decrease over a 1-year period. There was an indication that hypersensitivity to Coxsackie B4 was greatest 3 months after diagnosis.

MeSH Terms
Adolescent Adult Animals Antigens Antigens, Viral Autoantigens Autoimmune Diseases Cell Migration Inhibition Child Child, Preschool Coxsackievirus Infections Diabetes Mellitus, Type 1/etiology,immunology Enterovirus/immunology Female Humans Hypersensitivity, Delayed Immunity, Cellular Leukocytes/immunology Male Mitochondria, Liver/immunology Pancreas/immunology Rats
Chemicals
Antigens Antigens, Viral Autoantigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Richens E R
Ancil R J
References (34)
34 references, click to expand
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1976-01-00
Pages
40-6
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1538350
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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