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PMID: 12618399 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Evidence of a high rate of selective sweeps in African Drosophila melanogaster.

Genetics ·Vol. 163 ·No. 2 ·2003-02-00 ·Pages 599-609

Mousset S, Brazier L, Cariou ML, Chartois F, Depaulis F, Veuille M

Abstract

Assessing the rate of evolution depends on our ability to detect selection at several genes simultaneously. We summarize DNA sequence variation data in three new and six previously published data sets from the left arm of the second chromosome of Drosophila melanogaster in a population from West Africa, the presumed area of origin of this species. Four loci [Acp26Aa, Fbp2, Vha68-1, and Su(H)] were previously found to deviate from a neutral mutation-drift equilibrium as a consequence of one or several selective sweeps. Polymorphism data from five loci from intervening regions (dpp, Acp26Ab, Acp29AB, GH10711, and Sos) did not show the characteristic deviation from neutrality caused by local selective sweeps. This genomic region is polymorphic for the In(2L)t inversion. Four loci located near inversion breakpoints [dpp, sos, GH10711, and Su(H)] showed significant structuring between the two arrangements or significant deviation from neutrality in the inverted class, probably as a result of a recent shift in inversion frequency. Overall, these patterns of variation suggest that the four selective events were independent. Six loci were observed with no a priori knowledge of selection, and independent selective sweeps were detected in three of them. This suggests that a large part of the D. melanogaster genome has experienced the effect of positive selection in its ancestral African range.

MeSH Terms
Africa, Western Animals Base Sequence Chromosome Inversion Drosophila melanogaster/genetics Molecular Sequence Data Phylogeny Polymorphism, Genetic Selection, Genetic Sequence Analysis, DNA
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Mousset Sylvain
Laboratoire d'Ecologie, Ecole Pratique des Hautes Etudes, Université Pierre et Marie Curie, 75005 Paris, France.
Brazier Lionel
Cariou Marie-Louise
Chartois Frédérique
Depaulis Frantz
Veuille Michel
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/163.2.599
Published
2003-02-00
Pages
599-609
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1462469
Subset
IM
Databases
GENBANK
AF459524, AF459525, AF459526, AF459527, AF459528, AF459529, AF459530, AF459531, AF459532, AF459533, AF459534, AF459535, AF459536, AF459537, AF459538, AF459539, AF459540, AF459541, AF459542, AF459543, AF459544, AF459545, AF459546, AF459547, AF459548, AF459549, AF459550, AF459551, AF459552, AF459553, AF459554, AF459555, AF459556, AF459557, AF459558, AF459559, AF459560, AF459561, AF459562, AF459563, AF459564, AF459565, AF459566, AF459567, AF459568, AF459569, AF459570, AF459571, AF459572, AF459573, AF459574, AF459575, AF459576, AF459577, AF459578, AF459579, AF459580, AF459581, AF459582, AF459583, AF459584, AF459585, AF459586
External Links
PubMed source DOI: 10.1093/genetics/163.2.599 PMC Full Text View journal details
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