Soluble VEGF receptor Flt1: the elusive preeclampsia factor discovered?

The Journal of clinical investigation ·Vol. 111 ·No. 5 ·2003-03-00 ·Pages 600-2

Luttun A, Carmeliet P

Abstract

暂无摘要

MeSH Terms

Endothelium, Vascular/physiology Female Humans Neovascularization, Physiologic Pre-Eclampsia/etiology Pregnancy Vascular Endothelial Growth Factor Receptor-1/physiology

Chemicals

Vascular Endothelial Growth Factor Receptor-1

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Luttun Aernout

The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium.

Carmeliet Peter

References (9)

9 references, click to expand

Pathogenesis and genetics of pre-eclampsia.
Lancet. 2001 Jan 6;357(9249):53-6 PMID: 11197372
Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome.
Am J Pathol. 2002 Apr;160(4):1405-23 PMID: 11943725
Regulation of trophoblast invasion: from normal implantation to pre-eclampsia.
Mol Cell Endocrinol. 2002 Feb 22;187(1-2):233-8 PMID: 11988332
Loss of the VEGF(164) and VEGF(188) isoforms impairs postnatal glomerular angiogenesis and renal arteriogenesis in mice.
J Am Soc Nephrol. 2002 Jun;13(6):1548-60 PMID: 12039984
Preeclampsia. Part 1: clinical and pathophysiologic considerations.
Obstet Gynecol Surv. 2002 Sep;57(9):598-618 PMID: 12218668
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.
J Clin Invest. 2003 Mar;111(5):649-58 PMID: 12618519
Animal models of preeclampsia.
Semin Perinatol. 1999 Feb;23(1):2-13 PMID: 10102166
Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases.
J Clin Invest. 2003 Mar;111(5):707-16 PMID: 12618525
Ultrastructural differentiation of stromal and vascular components in early macaque placental villi.
Am J Anat. 1987 Jan;178(1):30-44 PMID: 2435141

Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI18015

Published

2003-03-00

Pages

600-2

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC151908

Subset

Corrections

CommentOn

PMID: 12618519

CommentOn

PMID: 12618525

External Links

PubMed source DOI: 10.1172/JCI18015 PMC Full Text View journal details

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Soluble VEGF receptor Flt1: the elusive preeclampsia factor discovered?

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