Types of enzymatic overdosing in trisomy 21: erythrocytic superoxide dismutase-AJ and phosphoglucomutase.

Humangenetik ·Vol. 29 ·No. 1 ·1975-08-29 ·Pages 79-83

Prişcu R, Sichitiu S

Abstract

A comparative study was carried out on the hemolysates of 6 trisomic 21 and 6 normal subjects, by electrophoresis in starch gel, determining by a combined staining method both SOD-A (former IPO-dimer) and PGM activity. The enzymes were found statistically to be in a hyperactive status, the ratio of trisomic to normal values being approximately equalt to 1.4. SOD-A supraactivation is the effect of a genic dose, as demonstrated in earlier works (Sichitiu, 1973; Sichitiu et al., 1974; Sinet et al., 1974), whereas PGM hyperactivity appears to be modified secondarily, the same as the activity of other cellular enzymes in Down's disease.

MeSH Terms

Chromosomes, Human, 21-22 and Y Down Syndrome/enzymology Enzyme Activation Erythrocytes/enzymology Genes Humans Phosphoglucomutase/blood Superoxide Dismutase/blood Trisomy

Chemicals

Superoxide Dismutase Phosphoglucomutase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Prişcu R

Sichitiu S

References (11)

11 references, click to expand

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Article Info

Journal

Humangenetik

Abbr.

Humangenetik

ISSN

0018-7348

DOI

10.1007/BF00273353

Published

1975-08-29

Pages

79-83

Language

English

Region

Germany

NLM ID

7607154

Subset

External Links

PubMed source DOI: 10.1007/BF00273353

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Types of enzymatic overdosing in trisomy 21: erythrocytic superoxide dismutase-AJ and phosphoglucomutase.

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