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PMID: 1266854 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

The frequency of "rare" protein variants in Marshall islanders and other Micronesians.

American journal of human genetics ·Vol. 28 ·No. 3 ·1976-05-00 ·Pages 262-9

Neel JV, Ferrell RE, Conard RA

Abstract

Blood specimens from a sample of 373 Marshall Islanders were studied with reference to variants of 23 serum proteins and erythrocyte enzymes. Six of the traits studied exhibited genetic polymorphisms (adenosine deaminase, phosphoglucomutase1, acid phosphatase, 6-phosphogluconate dehydrogenase, haptoglobin, and group specific component). There were in addition four "rare" variants (albumin, transferrin, lactate dehydrogenase, and galactose-1-phosphate uridylyltransferase) involving nine persons, among 8,503 determinations. The frequency of rare variants in Micronesians was compared with the frequencies in West European Caucasians and Amerindians. There are many difficulties in such comparisons, and although the observed values for the three ethnic groups differ by a factor of three (the Micronesians exhibiting the lowest frequency), it is felt that no firm conclusions concerning differences between ethnic groups can be drawn at this time.

MeSH Terms
Acid Phosphatase Adenosine Deaminase Asians Blood Proteins Enzymes Gene Frequency Genetic Variation Genetics, Population Haptoglobins Humans Micronesia Phenotype Phosphoglucomutase Phosphogluconate Dehydrogenase Polymorphism, Genetic
Chemicals
Blood Proteins Enzymes Haptoglobins Phosphogluconate Dehydrogenase Acid Phosphatase Adenosine Deaminase Phosphoglucomutase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Neel J V
Ferrell R E
Conard R A
References (19)
19 references, click to expand
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1976-05-00
Pages
262-9
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685014
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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