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PMID: 12669018 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Cytokine control of memory T-cell development and survival.

Nature reviews. Immunology ·Vol. 3 ·No. 4 ·2003-04-00 ·Pages 269-79

Schluns KS, Lefrançois L

Abstract

Evidence has accumulated that cytokines have a fundamental role in the differentiation of memory T cells. Here, we follow the CD8+ T cell from initial activation to memory-cell generation, indicating the checkpoints at which cytokines determine the fate of the T cell. Members of the common cytokine-receptor gamma-chain (gammac)-cytokine family--in particular, interleukin-7 (IL-7) and IL-15--act at each stage of the immune response to promote proliferation and survival. In this manner, a stable and protective, long-lived memory CD8+ T-cell pool can be propagated and maintained.

MeSH Terms
Animals Antigens CD4-Positive T-Lymphocytes/cytology,immunology CD8-Positive T-Lymphocytes/cytology,immunology Cell Differentiation/immunology Cell Survival/immunology Cytokines/genetics,physiology Gene Expression Humans Immunologic Memory Interleukin-15/physiology Interleukin-2/physiology Interleukin-7/physiology Lymphocyte Activation Models, Immunological Receptors, Cytokine/genetics,physiology Receptors, Interleukin-15 Receptors, Interleukin-2/physiology Receptors, Interleukin-7/physiology T-Lymphocyte Subsets/cytology,immunology
Chemicals
Antigens Cytokines IL15RA protein, human Interleukin-15 Interleukin-2 Interleukin-7 Receptors, Cytokine Receptors, Interleukin-15 Receptors, Interleukin-2 Receptors, Interleukin-7
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schluns Kimberly S
Division of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030-1319, USA.
Lefrançois Leo
Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1733
DOI
10.1038/nri1052
Published
2003-04-00
Pages
269-79
Language
English
Region
England
NLM ID
101124169
Subset
IM
External Links
PubMed source DOI: 10.1038/nri1052 View journal details
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