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PMID: 12687500 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: suggestive linkage on 17p11.

American journal of human genetics ·Vol. 72 ·No. 5 ·2003-05-00 ·Pages 1268-79

Ogdie MN, Macphie IL, Minassian SL, Yang M, Fisher SE, Francks C, Cantor RM, McCracken JT, McGough JJ, Nelson SF, Monaco AP, Smalley SL

Abstract

Attention-deficit/hyperactivity disorder (ADHD [MIM 143465]) is a common, highly heritable neurobehavioral disorder of childhood onset, characterized by hyperactivity, impulsivity, and/or inattention. As part of an ongoing study of the genetic etiology of ADHD, we have performed a genomewide linkage scan in 204 nuclear families comprising 853 individuals and 270 affected sibling pairs (ASPs). Previously, we reported genomewide linkage analysis of a "first wave" of these families composed of 126 ASPs. A follow-up investigation of one region on 16p yielded significant linkage in an extended sample. The current study extends the original sample of 126 ASPs to 270 ASPs and provides linkage analyses of the entire sample, using polymorphic microsatellite markers that define an approximately 10-cM map across the genome. Maximum LOD score (MLS) analysis identified suggestive linkage for 17p11 (MLS=2.98) and four nominal regions with MLS values >1.0, including 5p13, 6q14, 11q25, and 20q13. These data, taken together with the fine mapping on 16p13, suggest two regions as highly likely to harbor risk genes for ADHD: 16p13 and 17p11. Interestingly, both regions, as well as 5p13, have been highlighted in genomewide scans for autism.

MeSH Terms
Adolescent Attention Deficit Disorder with Hyperactivity/genetics Child Child, Preschool Chromosome Mapping Chromosomes, Human/genetics Chromosomes, Human, Pair 17/genetics Cohort Studies Female Genetic Linkage Genome Humans Los Angeles Male Sample Size Siblings
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Ogdie Matthew N
Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Macphie I Laurence
Minassian Sonia L
Yang May
Fisher Simon E
Francks Clyde
Cantor Rita M
McCracken James T
McGough James J
Nelson Stanley F
Monaco Anthony P
Smalley Susan L
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
DOI
10.1086/375139
Published
2003-05-00
Epub
2003-00-08
Pages
1268-79
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1180278
Subset
IM
Grants
NIMH NIH HHS · MH58277 · United States
NIGMS NIH HHS · GM07104 · United States
NIMH NIH HHS · R01 MH058277 · United States
NIGMS NIH HHS · T32 GM007104 · United States
NIMH NIH HHS · MH01969 · United States
NIMH NIH HHS · MH01805 · United States
NIMH NIH HHS · K24 MH001805 · United States
External Links
PubMed source DOI: 10.1086/375139 PMC Full Text View journal details
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