All roads lead to ATF4.

Developmental cell ·Vol. 4 ·No. 4 ·2003-04-00 ·Pages 442-4

Rutkowski DT, Kaufman RJ

Abstract

Multiple intracellular stress pathways converge on a single event--phosphorylation of the translation initiation factor eIF2alpha and subsequent translational activation of the transcription factor ATF4. Exploring the consequences of this event has highlighted the ways in which stress is sensed and responded to via many distinct pathways.

MeSH Terms

Activating Transcription Factor 4 Animals Antioxidants/metabolism DNA-Binding Proteins/genetics,metabolism Endoplasmic Reticulum/metabolism Eukaryotic Cells/metabolism Humans Proteins/genetics,metabolism Signal Transduction/genetics Stress, Physiological/genetics,metabolism Transcription Factors/genetics,metabolism eIF-2 Kinase/genetics,metabolism

Chemicals

ATF4 protein, human Antioxidants DNA-Binding Proteins Proteins Transcription Factors Activating Transcription Factor 4 PERK kinase eIF-2 Kinase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Rutkowski D Thomas

Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

Kaufman Randal J

Article Info

Journal

Developmental cell

Abbr.

Dev Cell

ISSN

1534-5807

DOI

10.1016/s1534-5807(03)00100-x

Published

2003-04-00

Pages

442-4

Language

English

Region

United States

NLM ID

101120028

Subset

External Links

PubMed source DOI: 10.1016/s1534-5807(03)00100-x View journal details

Analysis Services

All roads lead to ATF4.

Contact

WeChat Official Account