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PMID: 12690202 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Defective CD8 T cell memory following acute infection without CD4 T cell help.

Science (New York, N.Y.) ·Vol. 300 ·No. 5617 ·2003-04-11 ·Pages 339-42

Sun JC, Bevan MJ

Abstract

The CD8+ cytotoxic T cell response to pathogens is thought to be CD4+ helper T cell independent because infectious agents provide their own inflammatory signals. Mice that lack CD4+ T cells mount a primary CD8 response to Listeria monocytogenes equal to that of wild-type mice and rapidly clear the infection. However, protective memory to a challenge is gradually lost in the former animals. Memory CD8+ T cells from normal mice can respond rapidly, but memory CD8+ T cells that are generated without CD4 help are defective in their ability to respond to secondary encounters with antigen. The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development.

MeSH Terms
Adoptive Transfer Animals CD8-Positive T-Lymphocytes/immunology,transplantation Cytotoxicity, Immunologic Genes, MHC Class II Immunization Immunologic Memory Interferon-gamma/biosynthesis Listeria monocytogenes/genetics,immunology Listeriosis/immunology Mice Mice, Inbred C57BL Ovalbumin/biosynthesis,genetics,immunology T-Lymphocyte Subsets/immunology T-Lymphocytes, Helper-Inducer/immunology
Chemicals
Interferon-gamma Ovalbumin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sun Joseph C
Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
Bevan Michael J
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1083317
Published
2003-04-11
Pages
339-42
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC2778341
Subset
IM
Grants
Howard Hughes Medical Institute · United States
NIAID NIH HHS · R01 AI019335 · United States
NIAID NIH HHS · R01 AI019335-19 · United States
NIAID NIH HHS · AI 19335 · United States
Corrections
CommentIn
PMID: 12690179
External Links
PubMed source DOI: 10.1126/science.1083317 PMC Full Text View journal details
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