Activity of pyruvate dehydrogenase complex in the mammary gland of normal and diabetic rats.
After parturition there is a 10 fold increase in the actual and total activity of the PDH complex in the mammary gland, which can be explained by an increased amount of enzyme protein. There is a marked difference between the activity state of the PDH complex in the suckled and unsuckled gland of the same animals. In fasting rats the active form of the PDH complex is decreased. This effect is further enhanced by inhibition of suckling. In the diabetic state the PDHa activity is reduced, but the change is statistically insignificant. The decreased milk production during diabetes results from the reduction of the total mass of gland. The total activity of the PDH complex is the same in fetal and neonatal liver of the rat. Whereas the PDH complex is fully activated before parturition, there is a significant decrease in the active form of the pyruvate dehydrogenase complex in the liver of the newborn rats.
16 references, click to expand
-
Fatty acid biosynthesis in rabbit mammary gland during pregnancy and early lactation.Biochem J. 1972 Aug;128(5):1303-9 PMID: 4643704
-
Pyruvate dehydrogenase, the citrate condensing enzyme and the utilization of 14 C-labeled lactate, pyruvate and alanine by slices of lactating mammary gland and adenocarcinoma of mouse mammary gland.Proc Soc Exp Biol Med. 1973 Mar;142(3):954-62 PMID: 4348099
-
[Changes in the activity of pyruvate dehydrogenase in thiamine deficiency].Hoppe Seylers Z Physiol Chem. 1968 Aug;349(8):969-78 PMID: 5679932
-
Function of calcium ions in pyruvate dehydrogenase phosphatase activity.Biochem Biophys Res Commun. 1972 Oct 17;49(2):563-71 PMID: 4344895
-
Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase.Biochem J. 1974 May;140(2):225-37 PMID: 4375962
-
Adaptive changes in satellite systems related to lipogenesis in rat and sheep mammary gland and in adipose tissue.Eur J Biochem. 1973 Apr 2;34(1):188-98 PMID: 4144830
-
Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion.Arch Biochem Biophys. 1971 Apr;143(2):593-601 PMID: 4326833
-
Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase.Biochem J. 1972 Jun;128(1):161-3 PMID: 4343661
-
Properties of pyruvate dehydrogenase of rat mammary tissue and its changes during pregnancy, lactation and weaning.Biochem J. 1974 Jul;142(1):87-95 PMID: 4374188
-
Proceedings: Regulation of the pyruvate dehydrogenase complex in mammary tissue of the rat.Hoppe Seylers Z Physiol Chem. 1974 Oct;355(10):1241 PMID: 4461579
-
Active and inactive forms of pyruvate dehydrogenase in rat liver. Effect of starvation and refeeding and of insulin treatment on pyruvate-dehydrogenase interconversion.Eur J Biochem. 1972 Apr 11;26(3):426-33 PMID: 5036975
-
Protein measurement with the Folin phenol reagent.J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
-
Effect of alloxan-diabetes and treatment with anti-insulin serum on pathways of glucose metabolism in lactating rat mammary gland.Biochem J. 1968 Sep;109(3):407-17 PMID: 5693642
-
Metabolic adaptations during lactogenesis. Fatty acid synthesis in rabbit mammary tissue during pregnancy and lactation.Biochem J. 1974 Mar;138(3):373-9 PMID: 4154742
-
Effects of alloxan diabetes on lactational performance and mammary tissue metabolism in the rat.Endocrinology. 1971 Apr;88(4):863-7 PMID: 5542412
-
Variations in the activity of several enzymes in the mammary glands of non-pregnant, pregnant and lactating rabbits.Biochem J. 1970 Feb;116(4):657-61 PMID: 4244890
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