Prostaglandin release in canine acute haemorrhagic pancreatitis.

Gut ·Vol. 17 ·No. 1 ·1976-01-00 ·Pages 22-6

Glazer G, Bennett A

Abstract

Acute haemorrhagic pancreatitis was induced in greyhound dogs by a bile salt/trypsin injection into the main pancreatic duct. Prostaglandin-like activity in the pancreatic venous blood, right atrial blood, and arterial blood was measured by bioassay. Activity rose significantly in the pancreatic venous blood of test dogs but not in controls. Chromatographic analysis of the peritoneal exudate from the dogs with pancreatitis showed high levels of prostaglandin E-like material (mean 43 ng/ml prostaglandin E2 equivalents). It seems likely that prostaglandins contribute to the induced pancreatitis.

MeSH Terms

Acute Disease Amylases/blood Animals Bile Acids and Salts Blood Pressure/drug effects Dogs Heart Rate/drug effects Hemorrhage/chemically induced,metabolism Pancreatitis/blood,chemically induced,metabolism Prostaglandins/metabolism Trypsin

Chemicals

Bile Acids and Salts Prostaglandins Amylases Trypsin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Glazer G

Bennett A

References (17)

17 references, click to expand

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Article Info

Journal

Gut

Abbr.

Gut

ISSN

0017-5749

DOI

10.1136/gut.17.1.22

Published

1976-01-00

Pages

22-6

Language

English

Region

England

NLM ID

2985108R

PMCID

PMC1411043

Subset

External Links

PubMed source DOI: 10.1136/gut.17.1.22 PMC Full Text View journal details

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Prostaglandin release in canine acute haemorrhagic pancreatitis.

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