Home LiteratureArticle Details
PMID: 12707021 Published · ppublish English Comment Journal Article Review

Wnt signaling and pulmonary fibrosis.

The American journal of pathology ·Vol. 162 ·No. 5 ·2003-05-00 ·Pages 1393-7

Morrisey EE

Abstract

暂无摘要

MeSH Terms
Embryonic and Fetal Development Humans Lung/embryology,growth & development Proto-Oncogene Proteins/physiology Pulmonary Fibrosis/physiopathology Signal Transduction Wnt Proteins Zebrafish Proteins
Chemicals
Proto-Oncogene Proteins Wnt Proteins Zebrafish Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Morrisey Edward E
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. [email protected]
References (55)
55 references, click to expand
  1. Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development.
    Genes Dev. 1999 Dec 1;13(23):3149-59 PMID: 10601040
  2. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation.
    Development. 1999 Oct;126(20):4557-68 PMID: 10498690
  3. Defects in the regulation of beta-catenin in colorectal cancer.
    Adv Exp Med Biol. 1999;470:23-32 PMID: 10709671
  4. The molecular basis of lung morphogenesis.
    Mech Dev. 2000 Mar 15;92(1):55-81 PMID: 10704888
  5. Wnt signalling in mammalian development and cancer.
    Cancer Metastasis Rev. 1999;18(2):215-30 PMID: 10728985
  6. Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex.
    J Cell Biol. 2000 Jul 10;150(1):225-41 PMID: 10893270
  7. Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells.
    J Biol Chem. 2000 Aug 4;275(31):23790-7 PMID: 10806215
  8. Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism.
    Immunity. 2000 Jul;13(1):15-24 PMID: 10933391
  9. TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment?
    Am J Physiol Lung Cell Mol Physiol. 2000 Sep;279(3):L562-74 PMID: 10956632
  10. Inhibition of Wnt activity induces heart formation from posterior mesoderm.
    Genes Dev. 2001 Feb 1;15(3):316-27 PMID: 11159912
  11. FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo.
    Am J Physiol Lung Cell Mol Physiol. 2001 Apr;280(4):L705-15 PMID: 11238011
  12. Protein kinase CK2 in mammary gland tumorigenesis.
    Oncogene. 2001 May 31;20(25):3247-57 PMID: 11423974
  13. Branching and differentiation defects in pulmonary epithelium with elevated Gata6 expression.
    Mech Dev. 2001 Jul;105(1-2):105-14 PMID: 11429286
  14. Induction of ureter branching as a response to Wnt-2b signaling during early kidney organogenesis.
    Dev Dyn. 2001 Sep;222(1):26-39 PMID: 11507767
  15. Wnt7b regulates placental development in mice.
    Dev Biol. 2001 Sep 15;237(2):324-32 PMID: 11543617
  16. Expression of Tcf/Lef and sFrp and localization of beta-catenin in the developing mouse lung.
    Mech Dev. 2001 Dec;109(2):437-40 PMID: 11731265
  17. The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium.
    J Biol Chem. 2002 Jun 7;277(23):21061-70 PMID: 11914369
  18. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma.
    Cancer Cell. 2002 Apr;1(3):279-88 PMID: 12086864
  19. Wnt5a participates in distal lung morphogenesis.
    Dev Biol. 2002 Aug 1;248(1):68-81 PMID: 12142021
  20. Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis.
    Nature. 2002 Aug 8;418(6898):636-41 PMID: 12167861
  21. Wnt7b regulates mesenchymal proliferation and vascular development in the lung.
    Development. 2002 Oct;129(20):4831-42 PMID: 12361974
  22. Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis.
    Am J Pathol. 2003 May;162(5):1495-502 PMID: 12707032
  23. Familial fibrosing alveolitis.
    Ir J Med Sci. 1981 Jul;150(7):204-9 PMID: 7287360
  24. Structure of alveolar epithelial cells in patients with fibrotic lung disorders.
    Lab Invest. 1982 Jan;46(1):39-53 PMID: 7054589
  25. Familial idiopathic pulmonary fibrosis. Evidence of lung inflammation in unaffected family members.
    N Engl J Med. 1986 May 22;314(21):1343-7 PMID: 3702942
  26. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice.
    Cell. 1988 Nov 18;55(4):619-25 PMID: 3180222
  27. Increased production and immunohistochemical localization of transforming growth factor-beta in idiopathic pulmonary fibrosis.
    Am J Respir Cell Mol Biol. 1991 Aug;5(2):155-62 PMID: 1892646
  28. The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells.
    Mol Cell Biol. 1992 Jan;12(1):321-8 PMID: 1530877
  29. Wnt genes and vertebrate development.
    Curr Opin Genet Dev. 1994 Aug;4(4):523-8 PMID: 7950319
  30. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4.
    Nature. 1994 Dec 15;372(6507):679-83 PMID: 7990960
  31. Rat serum inhibits progression of alveolar epithelial cells toward the type I cell phenotype in vitro.
    Am J Respir Cell Mol Biol. 1995 Jan;12(1):50-5 PMID: 7811470
  32. Reversible transdifferentiation of alveolar epithelial cells.
    Am J Respir Cell Mol Biol. 1995 May;12(5):497-502 PMID: 7742013
  33. A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells.
    Mol Cell Biol. 1995 Aug;15(8):4616-22 PMID: 7623853
  34. Cytoskeletal protein modulation in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis. Possible role of transforming growth factor beta and tumor necrosis factor alpha.
    Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1):2163-9 PMID: 8520791
  35. Pulmonary malformation in transgenic mice expressing human keratinocyte growth factor in the lung.
    Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12461-5 PMID: 8618921
  36. Fibroblasts isolated after fibrotic lung injury induce apoptosis of alveolar epithelial cells in vitro.
    Am J Physiol. 1995 Dec;269(6 Pt 1):L819-28 PMID: 8572243
  37. Alterations in the alveolar epithelium after injury leading to pulmonary fibrosis.
    Histol Histopathol. 1996 Apr;11(2):463-83 PMID: 8861769
  38. Targeted disruption of the Wnt2 gene results in placentation defects.
    Development. 1996 Nov;122(11):3343-53 PMID: 8951051
  39. Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips.
    Development. 1996 Nov;122(11):3627-37 PMID: 8951078
  40. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.
    Science. 1997 Mar 21;275(5307):1787-90 PMID: 9065402
  41. Genetic predisposition of idiopathic pulmonary fibrosis.
    Curr Opin Pulm Med. 1997 Sep;3(5):336-40 PMID: 9331534
  42. Hepatocyte nuclear factor-3beta limits cellular diversity in the developing respiratory epithelium and alters lung morphogenesis in vivo.
    Dev Dyn. 1997 Nov;210(3):305-14 PMID: 9389455
  43. Wnt signaling: a common theme in animal development.
    Genes Dev. 1997 Dec 15;11(24):3286-305 PMID: 9407023
  44. Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung.
    Development. 1997 Dec;124(23):4867-78 PMID: 9428423
  45. Neural crest induction by Xwnt7B in Xenopus.
    Dev Biol. 1998 Feb 1;194(1):129-34 PMID: 9473337
  46. Beta-catenin: a key mediator of Wnt signaling.
    Curr Opin Genet Dev. 1998 Feb;8(1):95-102 PMID: 9529612
  47. Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus.
    Nat Genet. 1998 Sep;20(1):54-7 PMID: 9731531
  48. Sonic hedgehog is essential to foregut development.
    Nat Genet. 1998 Sep;20(1):58-61 PMID: 9731532
  49. Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney.
    Development. 1998 Nov;125(21):4225-34 PMID: 9753677
  50. Sonic hedgehog regulates branching morphogenesis in the mammalian lung.
    Curr Biol. 1998 Sep 24;8(19):1083-6 PMID: 9768363
  51. Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.
    Genes Dev. 1998 Oct 15;12(20):3156-61 PMID: 9784490
  52. Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung.
    Am J Physiol. 1998 Dec;275(6 Pt 1):L1192-9 PMID: 9843857
  53. A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo.
    Development. 1999 Mar;126(6):1211-23 PMID: 10021340
  54. The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors.
    Oncogene. 1999 May 6;18(18):2883-91 PMID: 10362259
  55. Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development.
    Development. 1999 Sep;126(18):4005-15 PMID: 10457010
Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
DOI
10.1016/S0002-9440(10)64271-X
Email
[email protected]
Published
2003-05-00
Pages
1393-7
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1851190
Subset
IM
Corrections
CommentOn
PMID: 12707032
External Links
PubMed source DOI: 10.1016/S0002-9440(10)64271-X PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2