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PMID: 12728637 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The major diabetes prevention trials.

Current diabetes reports ·Vol. 3 ·No. 2 ·2003-04-00 ·Pages 115-22

Tuomilehto J, Lindström J

Abstract

Type 2 diabetes (T2D) is a devastating disease with multiple complications affecting many tissues, most notably the cardiovascular system. To be able to prevent a chronic disease such as T2D, certain requirements have to be met. Knowledge about its natural history with a preclinical phase, modifiable risk factors, effective and simple screening tools to identify high-risk subjects, and effective intervention that is affordable and acceptable are necessary. In addition, the efficacy of the intervention has to be proven under a clinical trial setting. Several major lifestyle intervention trials have been successfully carried out, with consistent results: the risk of T2D in high-risk subjects can be halved, the effect of lifestyle changes is rapid, and benefits are similar in different ethnic groups. Thus, the prevention of T2D is possible in most high-risk subjects, but how to achieve this at the population level remains a major challenge.

MeSH Terms
Clinical Trials as Topic Diabetes Mellitus, Type 2/prevention & control Humans Hypoglycemic Agents/therapeutic use Life Style
Chemicals
Hypoglycemic Agents
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tuomilehto Jaakko
National Public Health Institute, Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, Mannerheimintie 166, Helsinki 00300, Finland. [email protected]
Lindström Jaana
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Article Info
Journal
Current diabetes reports
Abbr.
Curr Diab Rep
ISSN
1534-4827
DOI
10.1007/s11892-003-0034-9
Email
[email protected]
Published
2003-04-00
Pages
115-22
Language
English
Region
United States
NLM ID
101093791
Subset
IM
External Links
PubMed source DOI: 10.1007/s11892-003-0034-9 View journal details
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