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PMID: 1273593 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Bone cells in culture: morphologic transformation by hormones.

Science (New York, N.Y.) ·Vol. 192 ·No. 4246 ·1976-06-25 ·Pages 1340-3

Miller SS, Wolf AM, Arnaud CD

Abstract

Hormones and purine nucleosides and nucleotides induced cultured bone cells to transform transiently from a spherical to a stellate shape. Cytochalasin B also induced the transformation. The change was blocked by colchicine and vinblastine, but not by lumicolchicine or cycloheximide. This morphologic transformation may provide a dynamic model of hormone action and bone cell modulation in vitro.

MeSH Terms

Animals Bone and Bones/cytology Cell Differentiation/drug effects Cells, Cultured Colchicine/pharmacology Culture Media Epinephrine/pharmacology Hormones/pharmacology Parathyroid Hormone/pharmacology Purine Nucleosides/pharmacology Purine Nucleotides/pharmacology Rats Time Factors Vinblastine/pharmacology

Chemicals

Culture Media Hormones Parathyroid Hormone Purine Nucleosides Purine Nucleotides Vinblastine Colchicine Epinephrine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Miller S S

Wolf A M

Arnaud C D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.1273593

Published

1976-06-25

Pages

1340-3

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.1273593 View journal details

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