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PMID: 12737525 Published · ppublish English Journal Article Review

Usefulness of behavioral and electrophysiological studies in transgenic models of Alzheimer's disease.

Neurochemical research ·Vol. 28 ·No. 7 ·2003-07-00 ·Pages 1009-15

Sant'Angelo A, Trinchese F, Arancio O

Abstract

Over the past several years researchers have engineered many transgenic models of Alzheimer's disease. Since loss of memory is one of the major hallmarks of the disorder, the phenotypic characterization of these animals has included both behavioral tests which aim to evaluate learning abilities, and electrophysiological studies to analyze synaptic transmission and long-term potentiation, a widely studied cellular model of learning and memory. These studies are fundamental for the design of novel therapies for the treatment and/or prevention of Alzheimer's disease.

MeSH Terms
Alzheimer Disease/etiology,physiopathology,psychology Animals Animals, Genetically Modified/genetics Behavior, Animal Electrophysiology Memory Disorders/etiology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sant'Angelo Antonino
Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA.
Trinchese Fabrizio
Arancio Ottavio
References (55)
55 references, click to expand
  1. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice.
    Science. 1996 Oct 4;274(5284):99-102 PMID: 8810256
  2. Diagnosis of Alzheimer's disease.
    Arch Neurol. 1985 Nov;42(11):1097-105 PMID: 2864910
  3. Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease.
    J Biol Chem. 1996 Aug 23;271(34):20631-5 PMID: 8702810
  4. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.
    J Neurosci. 2000 Jun 1;20(11):4050-8 PMID: 10818140
  5. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes.
    Nat Med. 1998 Jan;4(1):97-100 PMID: 9427614
  6. Genetic neurodegenerative diseases: the human illness and transgenic models.
    Science. 1998 Nov 6;282(5391):1079-83 PMID: 9804539
  7. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.
    Proc Natl Acad Sci U S A. 1998 May 26;95(11):6448-53 PMID: 9600986
  8. Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.
    J Neurosci. 2002 May 1;22(9):3445-53 PMID: 11978821
  9. Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies.
    Psychopharmacology (Berl). 1997 Jul;132(2):107-24 PMID: 9266608
  10. Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory.
    DNA Cell Biol. 2001 Nov;20(11):737-44 PMID: 11788052
  11. Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology.
    Exp Neurol. 2001 Aug;170(2):326-44 PMID: 11476599
  12. Formation of beta-amyloid protein deposits in brains of transgenic mice.
    Nature. 1991 Jul 18;352(6332):239-41 PMID: 1906990
  13. Transgenic models of neurodegenerative diseases.
    Curr Opin Neurobiol. 1996 Oct;6(5):651-60 PMID: 8937830
  14. Recent work on Alzheimer's disease transgenics.
    Curr Opin Biotechnol. 1998 Dec;9(6):561-4 PMID: 9889140
  15. Apolipoprotein E and cognitive performance.
    Nature. 2000 Mar 23;404(6776):352-4 PMID: 10746713
  16. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.
    Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3228-33 PMID: 10077666
  17. Transgenic mouse models of Alzheimer's disease.
    Biochem Soc Trans. 1998 Aug;26(3):504-8 PMID: 9765905
  18. Mutant genes in familial Alzheimer's disease and transgenic models.
    Annu Rev Neurosci. 1998;21:479-505 PMID: 9530504
  19. Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice.
    Neurobiol Aging. 2001 May-Jun;22(3):377-85 PMID: 11378242
  20. The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.
    J Neurosci. 2002 Mar 1;22(5):1858-67 PMID: 11880515
  21. Transgenic and knockout mice in the study of neurodegenerative diseases.
    J Mol Med (Berl). 1996 Mar;74(3):111-26 PMID: 8846161
  22. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.
    Nat Neurosci. 1999 Mar;2(3):271-6 PMID: 10195221
  23. A synaptic model of memory: long-term potentiation in the hippocampus.
    Nature. 1993 Jan 7;361(6407):31-9 PMID: 8421494
  24. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.
    J Biol Chem. 2001 Jun 15;276(24):21562-70 PMID: 11279122
  25. Using knockout and transgenic mice to study neurophysiology and behavior.
    Physiol Rev. 1998 Oct;78(4):1131-63 PMID: 9790572
  26. Modeling Alzheimer's disease in transgenic mice: effect of age and of presenilin1 on amyloid biochemistry and pathology in APP/London mice.
    Exp Gerontol. 2000 Sep;35(6-7):831-41 PMID: 11053674
  27. List of transgenic and knockout mice: behavioral profiles.
    Mamm Genome. 2000 Apr;11(4):260-74 PMID: 10754101
  28. Transgenic mouse models of Alzheimer's disease.
    Trends Genet. 2001 Oct;17(10):S7-12 PMID: 11585670
  29. Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein.
    J Neurosci. 2001 Jul 1;21(13):4691-8 PMID: 11425896
  30. Modeling Alzheimer's disease in transgenic mice.
    J Fla Med Assoc. 1994 Sep;81(9):625-8 PMID: 7964589
  31. Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins.
    Neuron. 1995 Nov;15(5):1203-18 PMID: 7576662
  32. Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein.
    Behav Neurosci. 1999 Oct;113(5):982-90 PMID: 10571480
  33. Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein.
    Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5341-5 PMID: 7777509
  34. The use of null mutant mice to study complex learning and memory processes.
    Behav Genet. 1996 May;26(3):301-12 PMID: 8754253
  35. Genetics of mouse behavior: interactions with laboratory environment.
    Science. 1999 Jun 4;284(5420):1670-2 PMID: 10356397
  36. Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau.
    J Neurosci. 2002 Jan 1;22(1):133-41 PMID: 11756496
  37. Alzheimer transgenic mouse models come of age.
    Trends Neurosci. 1997 Jul;20(7):279-80 PMID: 9223216
  38. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.
    Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13287-92 PMID: 9371838
  39. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.
    Nature. 1999 Jul 8;400(6740):173-7 PMID: 10408445
  40. Transgenic mice for the amyloid precursor protein 695 isoform have impaired spatial memory.
    Neuroreport. 1991 Dec;2(12):781-4 PMID: 1686563
  41. Genetically modified mice and cognition.
    Curr Opin Neurobiol. 1998 Apr;8(2):272-80 PMID: 9635213
  42. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.
    Nature. 1988 Feb 11;331(6156):525-7 PMID: 2893289
  43. Transgenic mice expressing human beta-APP751, but not mice expressing beta-APP695, display early Alzheimer's disease-like histopathology.
    Ann N Y Acad Sci. 1993 Sep 24;695:224-7 PMID: 8239286
  44. Transgenic approaches to model Alzheimer's disease.
    Rev Neurosci. 2000;11(1):47-51 PMID: 10716654
  45. Short-term synaptic plasticity.
    Annu Rev Neurosci. 1989;12:13-31 PMID: 2648947
  46. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.
    Nature. 2002 Apr 4;416(6880):535-9 PMID: 11932745
  47. Transgenic mice and modeling Alzheimer's disease.
    Rev Neurosci. 1995 Apr-Jun;6(2):87-96 PMID: 8564026
  48. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.
    Nature. 2000 Dec 21-28;408(6815):982-5 PMID: 11140686
  49. Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease.
    Behav Brain Res. 1999 Sep;103(2):145-62 PMID: 10513583
  50. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.
    Nat Neurosci. 2002 May;5(5):452-7 PMID: 11941374
  51. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.
    Nature. 2000 Dec 21-28;408(6815):979-82 PMID: 11140685
  52. Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques.
    Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14675-80 PMID: 11724968
  53. Transgenic mouse models of Alzheimer's disease.
    Biochim Biophys Acta. 2000 Jul 26;1502(1):63-75 PMID: 10899432
  54. Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.
    Nature. 1997 May 29;387(6632):500-5 PMID: 9168112
  55. Assessing the effects of the 129/Sv genetic background on swimming navigation learning in transgenic mutants: a study using mice with a modified beta-amyloid precursor protein gene.
    Brain Res. 1997 Oct 10;771(1):1-13 PMID: 9383002
Article Info
Journal
Neurochemical research
Abbr.
Neurochem Res
ISSN
0364-3190
DOI
10.1023/a:1023251005197
Published
2003-07-00
Pages
1009-15
Language
English
Region
United States
NLM ID
7613461
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1023251005197 View journal details
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