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PMID: 12744466 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Morphological correlates of acute and permanent hearing loss during experimental pneumococcal meningitis.

Brain pathology (Zurich, Switzerland) ·Vol. 13 ·No. 2 ·2003-04-00 ·Pages 123-32

Klein M, Koedel U, Pfister HW, Kastenbauer S

Abstract

In patients with acute bacterial meningitis, hearing loss can be transient but is often permanent. The mechanisms underlying meningitis-associated hearing loss are not fully understood. Therefore, we investigated the morphological correlates of hearing loss in a rat model of pneumococcal meningitis. Transcutaneous intracisternal injection of Streptococcus pneumoniae resulted in a dose-dependent hearing loss (determined by auditory brainstem response audiometry), which was partially reversible during the acute stage. Nevertheless, a severe permanent hearing loss persisted until 2 weeks after infection. Suppurative labyrinthitis was accompanied by blood-labyrinth barrier disruption (determined by cochlear Evans blue extravasation), which correlated closely with hearing loss during the acute stage but not after recovery. Two weeks after infection, spiral ganglion neuronal density was markedly decreased and correlated with the severity of permanent hearing loss. Neuronal loss can be explained by the new finding of meningitis-associated spiral ganglion neuronal necrosis rather than apoptosis (determined by morphology, TUNEL staining, and immunohistochemistry).

MeSH Terms
Animals Capillary Permeability Cell Death Cochlea/pathology Disease Models, Animal Ear, Inner/blood supply,pathology Hearing Loss, Central/etiology,pathology In Situ Nick-End Labeling Labyrinthitis/complications,pathology Male Meningitis, Pneumococcal/complications,pathology Neurons/pathology Rats Rats, Wistar Spiral Ganglion/pathology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Klein Matthias
Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany.
Koedel Uwe
Pfister Hans-Walter
Kastenbauer Stefan
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Article Info
Journal
Brain pathology (Zurich, Switzerland)
Abbr.
Brain Pathol
ISSN
1015-6305
DOI
10.1111/j.1750-3639.2003.tb00012.x
Published
2003-04-00
Pages
123-32
Language
English
Region
Switzerland
NLM ID
9216781
PMCID
PMC8095810
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1750-3639.2003.tb00012.x PMC Full Text View journal details
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